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Mitochondrial DNA c...
Mitochondrial DNA copy number and future risk of B-cell lymphoma in a nested case-control study in the prospective EPIC cohort.
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Saberi Hosnijeh, Fatemeh (author)
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Lan, Qing (author)
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Rothman, Nathaniel (author)
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Liu, Chin San (author)
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Cheng, Wen-Ling (author)
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Nieters, Alexandra (author)
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Guldberg, Per (author)
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Tjønneland, Anne (author)
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Campa, Daniele (author)
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Martino, Alessandro (author)
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Boeing, Heiner (author)
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Trichopoulou, Antonia (author)
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Lagiou, Pagona (author)
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Trichopoulos, Dimitrios (author)
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Krogh, Vittorio (author)
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Tumino, Rosario (author)
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Panico, Salvatore (author)
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Masala, Giovanna (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Huerta Castaño, José María (author)
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Ardanaz, Eva (author)
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Sala, Núria (author)
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Dorronsoro, Miren (author)
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Quirós, J Ramón (author)
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Sánchez, María-José (author)
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- Melin, Beatrice (author)
- Umeå universitet,Onkologi
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- Johansson, Ann Sofie (author)
- Umeå universitet,Onkologi
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- Malm, Johan (author)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups
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- Borgquist, Signe (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Peeters, Petra H (author)
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Bueno-de-Mesquita, H Bas (author)
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Wareham, Nick (author)
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Khaw, Kay-Tee (author)
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Travis, Ruth C (author)
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Brennan, Paul (author)
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Siddiq, Afshan (author)
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Riboli, Elio (author)
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Vineis, Paolo (author)
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Vermeulen, Roel (author)
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(creator_code:org_t)
- American Society of Hematology, 2014
- 2014
- English.
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In: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 124:4, s. 530-535
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://europepmc.or...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- It has been suggested that mitochondrial dysfunction and DNA damage are involved in lymphomagenesis. Increased copy number of mitochondrial DNA (mtDNA) as a compensatory mechanism of mitochondrial dysfunction previously has been associated with B-cell lymphomas, in particular chronic lymphocytic leukemia (CLL). However, current evidence is limited and based on a relatively small number of cases. Using a nested case-control study, we extended these findings with a focus on subtype specific analyses. Relative mtDNA copy number was measured in the buffy coat of prospectively collected blood of 469 lymphoma cases and 469 matched controls. The association between mtDNA copy number and the risk of developing lymphoma and histologic subtypes was examined using logistic regression models. We found no overall association between mtDNA and risk of lymphoma. Subtype analyses revealed, significant increased risks of CLL (n=102) with increasing mtDNA copy number (OR=1.34, 1.44 and 1.80 for quartiles 2-4, respectively P-trend=0.001). mtDNA copy number was not associated with follow-up time suggesting that this observation is not strongly influenced by indolent disease status. This study substantially strengthens the evidence that mtDNA copy number is related to risk of CLL and supports the importance of mitochondrial dysfunction as a possible mechanistic pathway in CLL ontogenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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Blood
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To the university's database
- By the author/editor
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Saberi Hosnijeh, ...
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Lan, Qing
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Rothman, Nathani ...
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Liu, Chin San
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Cheng, Wen-Ling
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Nieters, Alexand ...
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show more...
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Guldberg, Per
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Tjønneland, Anne
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Campa, Daniele
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Martino, Alessan ...
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Boeing, Heiner
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Trichopoulou, An ...
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Lagiou, Pagona
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Trichopoulos, Di ...
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Krogh, Vittorio
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Tumino, Rosario
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Panico, Salvator ...
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Masala, Giovanna
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Weiderpass, Elis ...
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Huerta Castaño, ...
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Ardanaz, Eva
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Sala, Núria
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Dorronsoro, Mire ...
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Quirós, J Ramón
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Sánchez, María-J ...
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Melin, Beatrice
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Johansson, Ann S ...
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Malm, Johan
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Borgquist, Signe
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Peeters, Petra H
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Bueno-de-Mesquit ...
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Wareham, Nick
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Khaw, Kay-Tee
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Travis, Ruth C
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Brennan, Paul
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Siddiq, Afshan
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Riboli, Elio
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Vineis, Paolo
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Vermeulen, Roel
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Blood
- By the university
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Lund University
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Umeå University
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Karolinska Institutet