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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03513naa a2200361 4500 | |
| 001 | oai:lup.lub.lu.se:3aa77148-277f-45f6-9066-b3dc717e4ea9 | |
| 003 | SwePub | |
| 008 | 190122s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/3aa77148-277f-45f6-9066-b3dc717e4ea92 URI |
| 024 | 7 | a https://doi.org/10.1038/s41398-018-0336-y2 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Svensson, Thomasu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital,University of Tokyo,Keio University,National Cancer Center Tokyo4 aut0 (Swepub:lu)th4123sv |
| 245 | 1 0 | a The association between midlife serum high-density lipoprotein and mild cognitive impairment and dementia after 19 years of follow-up |
| 264 | c 2019-01-18 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2019 |
| 520 | a A third of dementia cases could be attributable to modifiable risk-factors. Midlife high-density lipoprotein cholesterol (HDL-C) is a measure which could help identify individuals at reduced risk of developing age-related cognitive decline. The Japan Public Health Centre-based prospective (JPHC) Study is a large population-based cohort which started in 1990. This study included 1299 participants from Saku area in Nagano prefecture. Participants had HDL-C measured in 1995-1996, and underwent a mental health screening in 2014-2015. Of these, 1114 participants were included in MCI analyses, and 781 participants were included in dementia analyses. Logistic regression models were used to determine odds ratios (OR) and 95% confidence intervals (CI) for the association between HDL-C quartiles and MCI and dementia, respectively. For dementia analysis, quartiles 2-4 were collapsed due to low number of cases. Missing data was addressed through multiple imputations. There were 386 cases of MCI and 53 cases of dementia. Compared to the lowest HDL-C quartile, the highest HDL-C quartile was significantly inversely associated with MCI (OR = 0.47, 95% CI, 0.28-0.79) in the multivariable analysis. High HDL-C (quartiles 2-4) was inversely associated with dementia compared to low HDL-C (quartile 1) (OR = 0.37, 95% CI, 0.16-0.88). This study has found that high midlife HDL-C levels are inversely associated with both late-life MCI and dementia in a Japanese population. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 700 | 1 | a Sawada, Norieu National Cancer Center Tokyo4 aut |
| 700 | 1 | a Mimura, Masaruu Keio University4 aut |
| 700 | 1 | a Nozaki, Shokou Keio University4 aut |
| 700 | 1 | a Shikimoto, Ryou Keio University4 aut |
| 700 | 1 | a Tsugane, Shoichirou National Cancer Center Tokyo4 aut |
| 710 | 2 | a Kardiovaskulär forskning - hypertonib Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Translational Psychiatryd : Springer Science and Business Media LLCg 9:1q 9:1x 2158-3188 |
| 856 | 4 | u http://dx.doi.org/10.1038/s41398-018-0336-yx freey FULLTEXT |
| 856 | 4 | u https://www.nature.com/articles/s41398-018-0336-y.pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/3aa77148-277f-45f6-9066-b3dc717e4ea9 |
| 856 | 4 8 | u https://doi.org/10.1038/s41398-018-0336-y |
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