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Genetic studies of ...
Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine
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- Schlosser, Pascal (author)
- Johns Hopkins Bloomberg School of Public Health
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- Scherer, Nora (author)
- Albert-Ludwigs University Freiburg
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- Grundner-Culemann, Franziska (author)
- Albert-Ludwigs University Freiburg
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- Monteiro-Martins, Sara (author)
- Albert-Ludwigs University Freiburg
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- Haug, Stefan (author)
- Albert-Ludwigs University Freiburg
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- Steinbrenner, Inga (author)
- Albert-Ludwigs University Freiburg
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- Uluvar, Burulça (author)
- University of Fribourg
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- Wuttke, Matthias (author)
- Albert-Ludwigs University Freiburg
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- Cheng, Yurong (author)
- Albert-Ludwigs University Freiburg
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- Ekici, Arif B (author)
- University Hospital Erlangen
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Gyimesi, Gergely (author)
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Karoly, Edward D (author)
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Kotsis, Fruzsina (author)
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Mielke, Johanna (author)
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- Gomez, Maria F (author)
- Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups
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Yu, Bing (author)
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Grams, Morgan E (author)
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Coresh, Josef (author)
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Boerwinkle, Eric (author)
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Köttgen, Michael (author)
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Kronenberg, Florian (author)
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Meiselbach, Heike (author)
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Mohney, Robert P (author)
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Akilesh, Shreeram (author)
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Schmidts, Miriam (author)
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Hediger, Matthias A (author)
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Schultheiss, Ulla T (author)
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Eckardt, Kai-Uwe (author)
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Oefner, Peter J (author)
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Sekula, Peggy (author)
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Li, Yong (author)
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Köttgen, Anna (author)
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(creator_code:org_t)
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- 2023
- 2023
- English.
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In: Nature Genetics. - 1546-1718. ; 55:6, s. 995-1008
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http://dx.doi.org/10... (free)
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Abstract
Subject headings
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- The kidneys operate at the interface of plasma and urine by clearing molecular waste products while retaining valuable solutes. Genetic studies of paired plasma and urine metabolomes may identify underlying processes. We conducted genome-wide studies of 1,916 plasma and urine metabolites and detected 1,299 significant associations. Associations with 40% of implicated metabolites would have been missed by studying plasma alone. We detected urine-specific findings that provide information about metabolite reabsorption in the kidney, such as aquaporin (AQP)-7-mediated glycerol transport, and different metabolomic footprints of kidney-expressed proteins in plasma and urine that are consistent with their localization and function, including the transporters NaDC3 (SLC13A3) and ASBT (SLC10A2). Shared genetic determinants of 7,073 metabolite-disease combinations represent a resource to better understand metabolic diseases and revealed connections of dipeptidase 1 with circulating digestive enzymes and with hypertension. Extending genetic studies of the metabolome beyond plasma yields unique insights into processes at the interface of body compartments.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Keyword
- Metabolome
- Kidney/metabolism
- Metabolomics
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Schlosser, Pasca ...
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Scherer, Nora
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Grundner-Culeman ...
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Monteiro-Martins ...
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Haug, Stefan
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Steinbrenner, In ...
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show more...
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Uluvar, Burulça
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Wuttke, Matthias
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Cheng, Yurong
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Ekici, Arif B
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Gyimesi, Gergely
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Karoly, Edward D
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Kotsis, Fruzsina
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Mielke, Johanna
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Gomez, Maria F
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Yu, Bing
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Grams, Morgan E
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Coresh, Josef
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Boerwinkle, Eric
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Köttgen, Michael
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Kronenberg, Flor ...
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Meiselbach, Heik ...
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Mohney, Robert P
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Akilesh, Shreera ...
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Schmidts, Miriam
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Hediger, Matthia ...
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Schultheiss, Ull ...
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Eckardt, Kai-Uwe
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Oefner, Peter J
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Sekula, Peggy
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Li, Yong
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Köttgen, Anna
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
- Articles in the publication
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Nature Genetics
- By the university
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Lund University