Sökning: onr:"swepub:oai:lup.lub.lu.se:56b1ed1a-1c21-494d-92d1-9cfbadf6785d" > Distinct and overla...
Fältnamn | Indikatorer | Metadata |
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000 | 04627naa a2200397 4500 | |
001 | oai:lup.lub.lu.se:56b1ed1a-1c21-494d-92d1-9cfbadf6785d | |
003 | SwePub | |
008 | 160404s2009 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:118188487 | |
024 | 7 | a https://lup.lub.lu.se/record/12894902 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1181884872 URI |
024 | 7 | a https://doi.org/10.4049/jimmunol.182.3.14602 DOI |
040 | a (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Cheng, Minu Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)med-mnc |
245 | 1 0 | a Distinct and overlapping patterns of cytokine regulation of thymic and bone marrow-derived NK cell development. |
264 | 1 | b The American Association of Immunologists,c 2009 |
520 | a Although bone marrow (BM) represents the main site for postnatal NK cell development, recently a distinct thymic-dependent NK cell pathway was identified. These studies were designed to investigate the role of cytokines in regulation of thymic NK cells and to compare with established regulatory pathways of BM-dependent NK cell compartment. The common cytokine receptor gamma-chain (Il2rg) essential for IL-15-induced signaling, and FMS-like tyrosine kinase 3 (FLT3) receptor ligand (Flt3l) were previously identified as important regulatory pathways of the BM NK cell compartment based on lack of function studies in mice, however their complementary action remains unknown. By investigating mice double-deficient in Il2rg and Flt3l (Flt3l(-/-) Il2rg(-/-)), we demonstrate that FLT3L is important for IL2Rg-independent maintenance of both immature BM as well as peripheral NK cells. In contrast to IL-7, which is dispensable for BM but important for thymic NK cells, IL-15 has a direct and important role in both thymic and BM NK cell compartments. Although thymic NK cells were not affected in Flt3l(-/-) mice, Flt3l(-/-)Il2rg(-/-) mice lacked detectable thymic NK cells, suggesting that FLT3L is also important for IL-2Rg-independent maintenance of thymic NK cells. Thus, IL-2Rg cytokines and FLT3L play complementary roles and are indispensable for homeostasis of both BM and thymic dependent NK cell development, suggesting that the cytokine pathways crucial for these two distinct NK cell pathways are largely overlapping. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
700 | 1 | a NozadCharoudeh, Hojjatollahu Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)med-hln |
700 | 1 | a Brodin, Petteru Karolinska Institutet4 aut |
700 | 1 | a Tang, Yanjuan4 aut |
700 | 1 | a Lakshmikanth, Tadepallyu Karolinska Institutet4 aut |
700 | 1 | a Höglund, Petteru Karolinska Institutet4 aut |
700 | 1 | a Jacobsen, Sten Eirik Wu Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,University of Oxford4 aut0 (Swepub:lu)stem-sja |
700 | 1 | a Sitnicka Quinn, Ewau Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)molm-esi |
710 | 2 | a Stamcellscentrum (SCC)b Avdelningen för stamcellsforskning4 org |
773 | 0 | t Journal of immunologyd : The American Association of Immunologistsg 182:3, s. 1460-1468q 182:3<1460-1468x 1550-6606x 0022-1767 |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/19155493?dopt=Abstracty FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/1289490 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:118188487 |
856 | 4 8 | u https://doi.org/10.4049/jimmunol.182.3.1460 |
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