Search: onr:"swepub:oai:lup.lub.lu.se:59f3da3f-9e51-4709-8cdd-12cf2c06440c" >
Meru couples planar...
-
Banerjee, Jennifer J.Francis Crick Institute
(author)
Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division
- Article/chapterEnglish2017
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:59f3da3f-9e51-4709-8cdd-12cf2c06440c
-
https://lup.lub.lu.se/record/59f3da3f-9e51-4709-8cdd-12cf2c06440cURI
-
https://doi.org/10.7554/eLife.25014DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g. the Par complexes for apical-basal polarity and the Frizzled/Dishevelled complex for PCP), a diverse array of polarized cells and tissues are generated. This suggests the existence of little-studied tissue-specific factors that rewire the core polarity modules to the appropriate conformation. In Drosophila sensory organ precursors (SOPs), the core PCP components initiate the planar polarization of apical-basal determinants, ensuring asymmetric division into daughter cells of different fates. We show that Meru, a RASSF9/RASSF10 homologue, is expressed specifically in SOPs, recruited to the posterior cortex by Frizzled/Dishevelled, and in turn polarizes the apical-basal polarity factor Bazooka (Par3). Thus, Meru belongs to a class of proteins that act cell/tissue-specifically to remodel the core polarity machinery.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Aerne, Birgit L.Francis Crick Institute
(author)
-
Holder, Maxine V.Francis Crick Institute
(author)
-
Hauri, SimonLund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine Proteomics,Forskargrupper vid Lunds universitet,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups(Swepub:lu)med-sh1
(author)
-
Gstaiger, MatthiasETH Zürich
(author)
-
Tapon, NicolasFrancis Crick Institute
(author)
-
Francis Crick InstituteInfektionsmedicin
(creator_code:org_t)
Related titles
Internet link
Find in a library
-
eLife
(Search for host publication in LIBRIS)
To the university's database