onr:"swepub:oai:lup.lub.lu.se:59f3da3f-9e51-4709-8cdd-12cf2c06440c"
Sökning: onr:"swepub:oai:lup.lub.lu.se:59f3da3f-9e51-4709-8cdd-12cf2c06440c" > Meru couples planar...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02942naa a2200337 4500 | |
| 001 | oai:lup.lub.lu.se:59f3da3f-9e51-4709-8cdd-12cf2c06440c | |
| 003 | SwePub | |
| 008 | 170809s2017 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/59f3da3f-9e51-4709-8cdd-12cf2c06440c2 URI |
| 024 | 7 | a https://doi.org/10.7554/eLife.250142 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Banerjee, Jennifer J.u Francis Crick Institute4 aut |
| 245 | 1 0 | a Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division |
| 264 | 1 | c 2017 |
| 520 | a Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g. the Par complexes for apical-basal polarity and the Frizzled/Dishevelled complex for PCP), a diverse array of polarized cells and tissues are generated. This suggests the existence of little-studied tissue-specific factors that rewire the core polarity modules to the appropriate conformation. In Drosophila sensory organ precursors (SOPs), the core PCP components initiate the planar polarization of apical-basal determinants, ensuring asymmetric division into daughter cells of different fates. We show that Meru, a RASSF9/RASSF10 homologue, is expressed specifically in SOPs, recruited to the posterior cortex by Frizzled/Dishevelled, and in turn polarizes the apical-basal polarity factor Bazooka (Par3). Thus, Meru belongs to a class of proteins that act cell/tissue-specifically to remodel the core polarity machinery. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
| 700 | 1 | a Aerne, Birgit L.u Francis Crick Institute4 aut |
| 700 | 1 | a Holder, Maxine V.u Francis Crick Institute4 aut |
| 700 | 1 | a Hauri, Simonu Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine Proteomics,Forskargrupper vid Lunds universitet,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups4 aut0 (Swepub:lu)med-sh1 |
| 700 | 1 | a Gstaiger, Matthiasu ETH Zürich4 aut |
| 700 | 1 | a Tapon, Nicolasu Francis Crick Institute4 aut |
| 710 | 2 | a Francis Crick Instituteb Infektionsmedicin4 org |
| 773 | 0 | t eLifeg 6q 6x 2050-084X |
| 856 | 4 | u http://dx.doi.org/10.7554/eLife.25014x freey FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/59f3da3f-9e51-4709-8cdd-12cf2c06440c |
| 856 | 4 8 | u https://doi.org/10.7554/eLife.25014 |
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