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Sökning: onr:"swepub:oai:lup.lub.lu.se:5c69202f-435d-4e63-a3da-862aa0f2b30b" > Second malignancies...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004375naa a2200577 4500
001oai:lup.lub.lu.se:5c69202f-435d-4e63-a3da-862aa0f2b30b
003SwePub
008160401s2011 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:123119655
0247 a https://lup.lub.lu.se/record/21613412 URI
0247 a https://doi.org/10.1002/ijc.261352 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1231196552 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Maule, Milena4 aut
2451 0a Second malignancies after childhood noncentral nervous system solid cancer: results from 13 cancer registries
264 c 2011-07-21
264 1b Wiley,c 2011
520 a Children diagnosed with noncentral nervous system solid cancers (NCNSSC) experience several adverse late effects, including second malignant neoplasm. The aim of our study was to assess the risk of specific second malignancies after a childhood NCNSSC. Diagnosis and follow-up data on 10,988 cases of NCNSSC in children (0-14 years) were obtained from 13 registries. Standardized incidence ratios (SIRs) with 95% confidence intervals (CI) and cumulative incidence of second malignancies were computed. We observed 175 second malignant neoplasms, yielding a SIR of 4.6, 95% CI: 3.9-5.3. When considering second cancers with at least 10 occurrences, highest relative risks were found for second malignant bone tumors (SIR = 26.4, 16.6-40.0), soft tissue sarcomas (SIR = 14.1, 6.7-25.8) and myeloid leukemia (SIR = 12.7, 6.3-22.8). Significant increased risks for all malignancies combined were observed after sympathetic nervous system tumors (SIR = 11.4, 5.2-21.6), retinoblastomas (SIR = 7.3, 5.4-9.8), renal tumors (SIR = 5.7, 3.8-8.0), malignant bone tumors (SIR = 5.6, 3.7-8.2), soft tissue sarcomas (SIR = 4.7, 3.2-6.8), germ-cell, trophoblastic and other gonadal neoplasms (SIR = 2.5, 1.1-4.9), carcinomas and other malignant epithelial neoplasms (SIR = 2.2, 1.4-3.3). The highest risk of a second malignancy of any type occurred 5 to 9 years after NCNSSC (SIR = 9.9, 6.8-13.9). The cumulative incidence of second malignancies 10 years after the first neoplasm was eight times higher among NCNSSC survivors than in the general population, with the absolute difference between observed and expected cumulative incidence still increasing after 50 years of follow-up. Children who survived a NCNSSC experience a large increased risk of developing a new malignancy, even many years after their initial diagnosis.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a second malignant neoplasm
653 a childhood solid cancer
7001 a Scelo, Ghislaine4 aut
7001 a Pastore, Guido4 aut
7001 a Brennan, Paul4 aut
7001 a Hemminki, Kariu Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-khk
7001 a Olsen, Jorgen H.4 aut
7001 a Tracey, Elizabeth4 aut
7001 a Pukkala, Eero4 aut
7001 a Weiderpass, Elisabeteu Karolinska Institutet4 aut
7001 a Brewster, David H.4 aut
7001 a Tamaro, Sharon4 aut
7001 a Chia, Kee-Seng4 aut
7001 a Pompe-Kirn, Vera4 aut
7001 a Kliewer, Erich V.4 aut
7001 a Tonita, Jon M.4 aut
7001 a Martos, Carmen4 aut
7001 a Jonasson, Jon G.4 aut
7001 a Merletti, Franco4 aut
7001 a Boffetta, Paolo4 aut
7102 a Allmänmedicin och klinisk epidemiologib Forskargrupper vid Lunds universitet4 org
7730 t International Journal of Cancerd : Wileyg 129:8, s. 1940-1952q 129:8<1940-1952x 0020-7136x 1097-0215
8564 u http://dx.doi.org/10.1002/ijc.26135y FULLTEXT
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.26135
8564 8u https://lup.lub.lu.se/record/2161341
8564 8u https://doi.org/10.1002/ijc.26135
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:123119655

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