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Sökning: onr:"swepub:oai:lup.lub.lu.se:5ca6a0f4-5ea1-4778-8447-439ec5e38cd9" > Natural history, ri...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005151naa a2200601 4500
001oai:lup.lub.lu.se:5ca6a0f4-5ea1-4778-8447-439ec5e38cd9
003SwePub
008161010s2016 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/5ca6a0f4-5ea1-4778-8447-439ec5e38cd92 URI
0247 a https://doi.org/10.1111/cen.131522 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Ahern, Tomásu University of Manchester4 aut
2451 0a Natural history, risk factors and clinical features of primary hypogonadism in ageing men : Longitudinal Data from the European Male Ageing Study
264 c 2016-08-18
264 1b Wiley,c 2016
520 a Objective: In ageing men, the incidence and clinical significance of testosterone (T) decline accompanied by elevated luteinizing hormone (LH) are unclear. We describe the natural history, risk factors and clinical features associated with the development of biochemical primary hypogonadism (PHG, T < 10·5 nmol/l and LH>9·4U/l) in ageing men. Design, Patients and Measurements: A prospective observational cohort survey of 3,369 community-dwelling men aged 40-79 years, followed up for 4·3 years. Men were classified as incident (i) PHG (eugonadal [EUG, T ≥ 10·5 nmol/l] at baseline, PHG at follow-up), persistent (p) PHG (PHG at baseline and follow-up), pEUG (EUG at baseline and follow-up) and reversed (r) PHG (PHG at baseline, EUG at follow-up). Predictors and changes in clinical features associated with the development of PHG were analysed by regression models. Results: Of 1,991 men comprising the analytical sample, 97·5% had pEUG, 1·1% iPHG, 1·1% pPHG and 0·3% rPHG. The incidence of PHG was 0·2%/year. Higher age (>70 years) [OR 12·48 (1·27-122·13), P = 0·030] and chronic illnesses [OR 4·24 (1·08-16·56); P = 0·038] predicted iPHG. Upon transition from EUG to PHG, erectile function, physical vigour and haemoglobin worsened significantly. Men with pPHG had decreased morning erections, sexual thoughts and haemoglobin with increased insulin resistance. Conclusions: Primary testicular failure in men is uncommon and predicted by old age and chronic illness. Some clinical features attributable to androgen deficiency, but not others, accompanied the T decline in men who developed biochemical PHG. Whether androgen replacement can improve sexual and/or physical function in elderly men with PHG merits further study.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Swiecicka, Agnieszkau University of Manchester4 aut
7001 a Eendebak, Robert J A Hu University of Manchester4 aut
7001 a Carter, Emma L.u University of Manchester4 aut
7001 a Finn, Joseph D.u University of Manchester4 aut
7001 a Pye, Stephen R.u University of Manchester4 aut
7001 a O'Neill, Terence W.u University of Manchester4 aut
7001 a Antonio, Leenu Catholic University of Leuven4 aut
7001 a Keevil, Brianu University Hospital of South Manchester NHS Foundation Trust4 aut
7001 a Bartfai, Györgyu University of Szeged4 aut
7001 a Casanueva, Felipe F.u University of Santiago de Compostela4 aut
7001 a Forti, Gianniu University of Florence4 aut
7001 a Giwercman, Aleksanderu Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)kir-agi
7001 a Han, Thang S.u Royal Holloway University of London4 aut
7001 a Kula, Krzysztofu Medical University of Lodz4 aut
7001 a Lean, Michael E Ju University of Glasgow4 aut
7001 a Pendleton, Neilu University of Manchester4 aut
7001 a Punab, Margusu University of Tartu4 aut
7001 a Rastrelli, Giuliau University of Florence4 aut
7001 a Rutter, Martin K.u Great Ormond Street Hospital4 aut
7001 a Vanderschueren, Dirku Catholic University of Leuven4 aut
7001 a Huhtaniemi, Ilpo T.u University of Turku4 aut
7001 a Wu, Frederick C Wu University of Manchester4 aut
7102 a University of Manchesterb Catholic University of Leuven4 org
7102 a EMAS Study Group
7730 t Clinical Endocrinologyd : Wileyg 85:6, s. 891-901q 85:6<891-901x 0300-0664
8564 u http://dx.doi.org/10.1111/cen.13152y FULLTEXT
8564 u https://www.research.manchester.ac.uk/portal/files/36917913/Ahern_et_al_2016_Clinical_Endocrinology.pdf
8564 8u https://lup.lub.lu.se/record/5ca6a0f4-5ea1-4778-8447-439ec5e38cd9
8564 8u https://doi.org/10.1111/cen.13152

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