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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005123naa a2200421 4500
001oai:lup.lub.lu.se:60437e2d-ea6b-49ef-ae69-54b530dc4c51
003SwePub
008161223s2016 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/60437e2d-ea6b-49ef-ae69-54b530dc4c512 URI
0247 a https://doi.org/10.1186/s13293-016-0120-82 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Andersson, Gustavu Lund University,Lunds universitet,Personlig patologi och cancerbehandling,Forskargrupper vid Lunds universitet,Personalized Pathology & Cancer Therapy,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)gu3276an
2451 0a Pancreatic cancer risk in relation to sex, lifestyle factors, and pre-diagnostic anthropometry in the Malmö Diet and Cancer Study
264 c 2016-12-09
264 1b Springer Science and Business Media LLC,c 2016
520 a Background: Lifestyle factors may influence the risk of developing pancreatic cancer. Whereas cigarette smoking is an established risk factor, the effects of high alcohol intake and obesity are more uncertain. The aim of the present study was to examine the associations of pre-diagnostic anthropometry, alcohol consumption, and smoking habits with pancreatic cancer risk in a Swedish prospective, population-based cohort, with particular reference to potential sex differences. Methods: The studied cohort consists of 28,098 participants, including all incident cases of pancreatic cancer, in the Malmö Diet and Cancer Study up until December 31, 2013 (n = 163). Non-parametric and chi-squared tests were applied to compare the distribution of risk factors between cases and non-cases. Cox regression proportional hazards models were used to estimate the relationship between investigative factors and pancreatic cancer risk. Anthropometric factors included height, weight, body mass index (BMI), waist and hip circumference, waist-hip ratio (WHR), and body fat percentage. Results: BMI was not a significant risk factor for pancreatic cancer, but a higher WHR was significantly associated with an increased risk in the entire cohort (hazard ratio (HR) 2.36, 95% confidence interval (CI) 1.28-4.35, p for trend = 0.009). Regular smoking was a significant risk factor among both women (HR 2.62, 95% CI 1.61-4.27) and men (HR 3.57, 95% CI 1.70-7.47), whereas occasional smoking was a significant risk factor only in women (HR 3.29, 95% CI 1.50-7.19). Passive smoking at work for >20 years was significantly associated with an increased risk in the entire cohort (HR 1.73, 95% CI 1.15-2.58) and in women selectively (HR 2.01, 95% CI 1.21-3.31). Alcohol consumption was not a significant risk factor. A significant interaction was found between female sex and age (p = 0.045), but no other factor, in relation to pancreatic cancer risk. Conclusions: WHR was the only pre-diagnostic anthropometric factor associated with pancreatic cancer risk, with no sex-related differences. Regular smoking was confirmed as a significant risk factor in both sexes, whereas occasional and passive smoking were significant risk factors only in women. Despite the lack of a significant interaction between smoking and sex in relation with pancreatic cancer risk, potential sex differences should be considered in future epidemiological studies.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Alcohol
653 a Lifestyle
653 a Obesity
653 a Pancreatic cancer risk
653 a Smoking
7001 a Wennersten, Christofferu Lund University,Skåne University Hospital4 aut
7001 a Borgquist, Signeu Lund University,Lunds universitet,Bröstcancer - prevention & intervention,Forskargrupper vid Lunds universitet,Breast cancer prevention & intervention,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)ront-sbo
7001 a Jirström, Karinu Lund University,Lunds universitet,Personlig patologi och cancerbehandling,Forskargrupper vid Lunds universitet,Personalized Pathology & Cancer Therapy,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)pat-kji
7102 a Personlig patologi och cancerbehandlingb Forskargrupper vid Lunds universitet4 org
7730 t Biology of Sex Differencesd : Springer Science and Business Media LLCg 7:1q 7:1x 2042-6410
8564 u http://dx.doi.org/10.1186/s13293-016-0120-8x freey FULLTEXT
8564 u https://bsd.biomedcentral.com/track/pdf/10.1186/s13293-016-0120-8
8564 8u https://lup.lub.lu.se/record/60437e2d-ea6b-49ef-ae69-54b530dc4c51
8564 8u https://doi.org/10.1186/s13293-016-0120-8

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