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Sökning: onr:"swepub:oai:lup.lub.lu.se:637968ad-53c8-4130-965a-7eee234a9c74" > Detection of lamini...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003166naa a2200433 4500
001oai:lup.lub.lu.se:637968ad-53c8-4130-965a-7eee234a9c74
003SwePub
008160401s2005 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/2479392 URI
0247 a https://doi.org/10.1111/j.0022-202X.2005.23646.x2 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Bekou, V4 aut
2451 0a Detection of laminin 5-specific auto-antibodies in mucous membrane and bullous pemphigoid sera by ELISA
264 1c 2005
520 a Mucous membrane pemphigoid (MMP) is an autoimmune bullous disease that primarily affects mucous membranes leading to a scarring phenotype. MMP patients produce auto-antibodies (auto-ab) that preferentially recognize two components of the dermoepidermal basement membrane zone (BMZ): bullous pemphigoid (BP)180 and laminin 5 (LN5). Since detection of disease-specific auto-ab may be critical for diagnosis of MMP, we developed an ELISA with affinity-purified native human LN5. A total of 24 MMP, 72 BP, and 51 control sera were analyzed for LN5-specific auto-ab: 18/24 (75.0%) MMP and 29/72 (40.3%) BP sera were LN5 reactive. Sensitivity and specificity of the LN5 ELISA for MMP were 75% and 84.3%, respectively, and 40.3% and 88.2% for BP, respectively. The LN5 ELISA was more sensitive than a dot blot assay with native LN5, which detected LN5-reactive IgG in 14/24 (58.3%) MMP and 16/72 (22.2%) BP sera. In MMP, but not BP, levels of LN5-reactive IgG correlated with disease severity. Furthermore, IgG reactivity to LN5 of the MMP and BP sera was not significantly associated with IgG reactivity against other autoantigens of the BMZ, such as BP180 or BP230. Thus, the established LN5 ELISA holds great promise as a novel diagnostic and prognostic parameter for MMP.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Dermatologi och venereologi0 (SwePub)302042 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Dermatology and Venereal Diseases0 (SwePub)302042 hsv//eng
653 a BP180
653 a dermoepidermal junction-auto-antibody
653 a laminin 5
653 a pemphigoid
7001 a Thoma-Uszynski, S4 aut
7001 a Wendler, O4 aut
7001 a Uter, W4 aut
7001 a Schwietzke, S4 aut
7001 a Hunziker, T4 aut
7001 a Zouboulis, C C4 aut
7001 a Schuler, G4 aut
7001 a Sorokin, Lydiau Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pat-lso
7001 a Hertl, M4 aut
7102 a Tumörmikromiljöb Sektion I4 org
7730 t Journal of Investigative Dermatologyg 124:4, s. 732-740q 124:4<732-740x 1523-1747
8564 u http://dx.doi.org/10.1111/j.0022-202X.2005.23646.xx freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/247939
8564 8u https://doi.org/10.1111/j.0022-202X.2005.23646.x

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