Sökning: onr:"swepub:oai:lup.lub.lu.se:65db3efa-807a-4b5f-85ca-19d39051b1e0" > Absolute Risk Predi...
Fältnamn | Indikatorer | Metadata |
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000 | 03789naa a2200505 4500 | |
001 | oai:lup.lub.lu.se:65db3efa-807a-4b5f-85ca-19d39051b1e0 | |
003 | SwePub | |
008 | 160404s2012 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/32186412 URI |
024 | 7 | a https://doi.org/10.1200/JCO.2012.41.89962 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Kovalchik, Stephanie A4 aut |
245 | 1 0 | a Absolute Risk Prediction of Second Primary Thyroid Cancer Among 5-Year Survivors of Childhood Cancer. |
264 | 1 | c 2012 |
520 | a PURPOSEWe developed three absolute risk models for second primary thyroid cancer to assist with long-term clinical monitoring of childhood cancer survivors. PATIENTS AND METHODSWe used data from the Childhood Cancer Survivor Study (CCSS) and two nested case-control studies (Nordic CCSS; Late Effects Study Group). Model M1 included self-reported risk factors, model M2 added basic radiation and chemotherapy treatment information abstracted from medical records, and model M3 refined M2 by incorporating reconstructed radiation absorbed dose to the thyroid. All models were validated in an independent cohort of French childhood cancer survivors.ResultsM1 included birth year, initial cancer type, age at diagnosis, sex, and past thyroid nodule diagnosis. M2 added radiation (yes/no), radiation to the neck (yes/no), and alkylating agent (yes/no). Past thyroid nodule was consistently the strongest risk factor (M1 relative risk [RR ], 10.8; M2 RR, 6.8; M3 RR, 8.2). In the validation cohort, 20-year absolute risk predictions for second primary thyroid cancer ranged from 0.04% to 7.4% for M2. Expected events agreed well with observed events for each model, indicating good calibration. All models had good discriminatory ability (M1 area under the receiver operating characteristics curve [AUC ], 0.71; 95% CI, 0.64 to 0.77; M2 AUC, 0.80; 95% CI, 0.73 to 0.86; M3 AUC, 0.75; 95% CI, 0.69 to 0.82). CONCLUSIONWe developed and validated three absolute risk models for second primary thyroid cancer. Model M2, with basic prior treatment information, could be useful for monitoring thyroid cancer risk in childhood cancer survivors. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Ronckers, Cécile M4 aut |
700 | 1 | a Veiga, Lene H S4 aut |
700 | 1 | a Sigurdson, Alice J4 aut |
700 | 1 | a Inskip, Peter D4 aut |
700 | 1 | a de Vathaire, Florent4 aut |
700 | 1 | a Sklar, Charles A4 aut |
700 | 1 | a Donaldson, Sarah S4 aut |
700 | 1 | a Anderson, Haraldu Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-han |
700 | 1 | a Bhatti, Parveen4 aut |
700 | 1 | a Hammond, Sue4 aut |
700 | 1 | a Leisenring, Wendy M4 aut |
700 | 1 | a Mertens, Ann C4 aut |
700 | 1 | a Smith, Susan A4 aut |
700 | 1 | a Stovall, Marilyn4 aut |
700 | 1 | a Tucker, Margaret A4 aut |
700 | 1 | a Weathers, Rita E4 aut |
700 | 1 | a Robison, Leslie L4 aut |
700 | 1 | a Pfeiffer, Ruth M4 aut |
710 | 2 | a Medicinsk onkologib Sektion I4 org |
773 | 0 | t Journal of Clinical Oncologyx 1527-7755 |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/23169509?dopt=Abstracty FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1200/JCO.2012.41.8996y FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/3218641 |
856 | 4 8 | u https://doi.org/10.1200/JCO.2012.41.8996 |
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