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Synthesis, in vitro...
Synthesis, in vitro, and in vivo evaluation of phosphate ester derivatives of combretastatin A-4
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Hadimani, MB (author)
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- Hua, Jianyi (author)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
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Jonklaas, MD (author)
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Kessler, RJ (author)
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- Sheng, Yezhou (author)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
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Olivares, A (author)
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Tanpure, RP (author)
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Weiser, A (author)
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Zhang, JX (author)
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- Edvardsen, Klaus (author)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
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Kane, RR (author)
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Pinney, KG (author)
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(creator_code:org_t)
- 2003
- 2003
- English.
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In: Bioorganic & Medicinal Chemistry Letters. - 0960-894X. ; 13:9, s. 1505-1508
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Combretastatin A-4 disodiumphosphate (CA4P), a prodrug formulation of the natural product combretastatin A-4 (CA4), is currently in clinical investigation for the treatment of cancer. In vivo, CA4P is rapidly enzymatically converted to CA4, a potent inhibitor of tubulin polymerization (IC50 = 1-2 muM), and rapidly causes bloodflow shutdown in tumor tissues. A variety of alkyl and aryl di- and triesters of CA4P have been synthesized and evaluated as potential CA4 prodrugs and/or stable CAV analogues. (C) 2003 Elsevier Science Ltd. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Hadimani, MB
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Hua, Jianyi
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Jonklaas, MD
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Kessler, RJ
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Sheng, Yezhou
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Olivares, A
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show more...
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Tanpure, RP
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Weiser, A
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Zhang, JX
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Edvardsen, Klaus
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Kane, RR
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Pinney, KG
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Bioorganic & Med ...
- By the university
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Lund University