Sökning: onr:"swepub:oai:lup.lub.lu.se:75a564f3-2ebf-43ff-9b2b-49b0d3bb51e2" > Osteopontin and dis...
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000 | 10179naa a2201033 4500 | |
001 | oai:lup.lub.lu.se:75a564f3-2ebf-43ff-9b2b-49b0d3bb51e2 | |
003 | SwePub | |
008 | 190528s2019 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:liu-156906 | |
009 | oai:prod.swepub.kib.ki.se:140803375 | |
024 | 7 | a https://lup.lub.lu.se/record/75a564f3-2ebf-43ff-9b2b-49b0d3bb51e22 URI |
024 | 7 | a https://doi.org/10.3899/jrheum.1807132 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1569062 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1408033752 URI |
040 | a (SwePub)lud (SwePub)liud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Wirestam, Lina,d 1986-u Linköpings universitet,Linköping University,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten4 aut0 (Swepub:liu)linwi45 |
245 | 1 0 | a Osteopontin and disease activity in patients with recent-onset systemic Lupus Erythematosus : Results from the SLICC Inception Cohort |
264 | c 2019-01-15 | |
264 | 1 | b The Journal of Rheumatology,c 2019 |
500 | a Funding Agencies|Swedish Rheumatism Association; County Council of Ostergotland; Swedish Society of Medicine; King Gustaf V and Queen Victorias Freemasons foundation; King Gustaf Vs 80-year anniversary foundation; Hanyang University [201600000001387]; Lupus UK; NIHR/Wellcome Trust Clinical Research Facility; US National Institutes of Health (NIH) [AR43727]; Singer Family Fund for Lupus Research; Arthritis Research UK; NIHR Manchester Biomedical Research Centre; NIHR/Wellcome Trust Clinical Research Facility at Manchester University National Health Service (NHS) Foundation Trust; Danish Rheumatism Association [A1028]; NIH [RR00046] | |
520 | a Objective. In cross-sectional studies, elevated osteopontin (OPN) levels have been proposed to reflect, and/or precede, progressive organ damage and disease severity in systemic lupus erythematosus (SLE). We aimed, in a cohort of patients with recent-onset SLE, to determine whether raised serum OPN levels precede damage and/or are associated with disease activity or certain disease phenotypes. Methods. We included 344 patients from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort who had 5 years of followup data available. All patients fulfilled the 1997 American College of Rheumatology (ACR) criteria. Baseline sera from patients and from age- and sex-matched population-based controls were analyzed for OPN using ELISA. Disease activity and damage were assessed at each annual followup visit using the SLE Disease Activity Index 2000 (SLEDAI-2K) and the SLICC/ACR damage index (SDI), respectively. Results. Compared to controls, baseline OPN was raised 4-fold in SLE cases (p < 0.0001). After relevant adjustments in a binary logistic regression model, OPN levels failed to significantly predict global damage accrual defined as SDI ≥ 1 at 5 years. However, baseline OPN correlated with SLEDAI-2K at enrollment into the cohort (r = 0.27, p < 0.0001), and patients with high disease activity (SLEDAI-2K ≥ 5) had raised serum OPN (p < 0.0001). In addition, higher OPN levels were found in patients with persistent disease activity (p = 0.0006), in cases with renal involvement (p < 0.0001) and impaired estimated glomerular filtration rate (p = 0.01). Conclusion. The performance of OPN to predict development of organ damage was not impressive. However, OPN associated significantly with lupus nephritis and with raised disease activity at enrollment, as well as over time. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
653 | a Biomarkers | |
653 | a Disease Activity | |
653 | a Organ Damage | |
653 | a Osteopontin | |
653 | a Prognosis | |
653 | a Systemic Lupus Erythematosus | |
653 | a SYSTEMIC LUPUS ERYTHEMATOSUS; BIOMARKERS; OSTEOPONTIN; DISEASE ACTIVITY; ORGAN DAMAGE; PROGNOSIS | |
700 | 1 | a Enocsson, Helena,d 1982-u Linköpings universitet,Linköping University,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten4 aut0 (Swepub:liu)helen05 |
700 | 1 | a Skogh, Thomas,d 1952-u Linköpings universitet,Linköping University,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland4 aut0 (Swepub:liu)thosk00 |
700 | 1 | a Padyukov, Leonidu Karolinska Institutet4 aut |
700 | 1 | a Jönsen, Andreasu Lund University,Lunds universitet,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Lund University Research Groups,Lund Univ, Sweden4 aut0 (Swepub:lu)reum-ajo |
700 | 1 | a Urowitz, Murray B.u University of Toronto,Toronto Western Hosp, Canada; Univ Toronto, Canada4 aut |
700 | 1 | a Gladman, Dafna D.u University of Toronto,Toronto Western Hosp, Canada; Univ Toronto, Canada4 aut |
700 | 1 | a Romero-DIaz, Juanitau Instituto Nacional de Ciencias Médicas y Nutrición,Inst Nacl Ciencias Med and Ntur, IL USA4 aut |
700 | 1 | a Bae, Sang Cheolu Hanyang University Medical Center,Hanyang Univ Hosp Rheumat Dis, South Korea4 aut |
700 | 1 | a Fortin, Paul R.u Laval University,Univ Laval, Canada4 aut |
700 | 1 | a Sanchez-Guerrero, Jorgeu University of Toronto,Univ Toronto, Canada; Toronto Western Hosp, Canada4 aut |
700 | 1 | a Clarke, Ann E.u University of Calgary,Univ Calgary, Canada4 aut |
700 | 1 | a Bernatsky, Sashau McGill University Health Center,McGill Univ, Canada4 aut |
700 | 1 | a Gordon, Carolineu University of Birmingham,Univ Birmingham, England4 aut |
700 | 1 | a Hanly, John G.u Dalhousie University,Queen Elizabeth 2 Hlth Sci Ctr, Canada; Queen Elizabeth 2 Hlth Sci Ctr, Canada; Dalhousie Univ, Canada4 aut |
700 | 1 | a Wallace, Danielu University of California, Los Angeles,Univ Calif Los Angeles, CA 90095 USA4 aut |
700 | 1 | a Isenberg, David A.u University College London,UCL, England,Columbia Univ, NY USA4 aut |
700 | 1 | a Rahman, Anisuru University College London,UCL, England4 aut |
700 | 1 | a Merrill, Joanu Oklahoma Medical Research Foundation,Oklahoma Med Res Fdn, OK 73104 USA4 aut |
700 | 1 | a Ginzler, Ellenu SUNY Downstate Health Sciences University,SUNY New York, NY USA4 aut |
700 | 1 | a Alarcón, Graciela S.u University of Alabama,Univ Alabama Birmingham, AL 35294 USA4 aut |
700 | 1 | a Chatham, W. Winnu University of Alabama,Univ Alabama Birmingham, AL 35294 USA4 aut |
700 | 1 | a Petri, Michelleu Johns Hopkins University School of Medicine,Johns Hopkins Univ, MD USA4 aut |
700 | 1 | a Khamashta, Muntheru University College London,St Thomas Hosp, England4 aut |
700 | 1 | a Aranow, Cynthiau Feinstein Institute for Medical Research,Feinstein Inst Med Res, NY USA4 aut |
700 | 1 | a MacKay, Megganu Feinstein Institute for Medical Research,Feinstein Inst Med Res, NY USA4 aut |
700 | 1 | a Dooley, Mary Anneu University of North Carolina,Univ N Carolina, NC 27515 USA4 aut |
700 | 1 | a Manzi, Susanu Allegheny Health Network,Autoimmun Inst, PA USA4 aut |
700 | 1 | a Ramsey-Goldman, Rosalindu Northwestern University,Northwestern Univ, IL USA; Feinberg Sch Med, IL USA4 aut |
700 | 1 | a Nived, Olau Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Sweden4 aut0 (Swepub:lu)reum-oni |
700 | 1 | a Steinsson, Kristjanu Fossvogur Landspitali Univ Hosp, Iceland4 aut |
700 | 1 | a Zoma, Asadu Hairmyres Hosp, Scotland4 aut |
700 | 1 | a Ruiz-Irastorza, Guillermou University of the Basque Country,Univ Basque Country, Spain4 aut |
700 | 1 | a Lim, Samu Emory University,Emory Univ, GA 30322 USA4 aut |
700 | 1 | a Kalunian, Kenu Univ Calif San Diego, CA 92093 USA4 aut |
700 | 1 | a Inanc, Muratu Istanbul Univ, Turkey4 aut |
700 | 1 | a Van Vollenhoven, Ronaldu Karolinska Institutet4 aut |
700 | 1 | a Ramos-Casals, Manuelu Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),IDIBAPS, Spain4 aut |
700 | 1 | a Kamen, Diane L.u Medical University of South Carolina,Med Univ South Carolina, SC 29425 USA4 aut |
700 | 1 | a Jacobsen, Sørenu Copenhagen University Hospital,Copenhagen Univ Hosp, Denmark4 aut |
700 | 1 | a Peschken, Christineu University of Manitoba,Univ Manitoba, Canada4 aut |
700 | 1 | a Askanase, Ancau Columbia University4 aut |
700 | 1 | a Stoll, Thomasu Kantousspital, Switzerland4 aut |
700 | 1 | a Bruce, Ian N.u University of Manchester,Univ Manchester, England; Manchester Univ Fdn Trust, England4 aut |
700 | 1 | a Wetterö, Jonas,d 1972-u Linköpings universitet,Linköping University,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten4 aut0 (Swepub:liu)jonwe26 |
700 | 1 | a Sjöwall, Christoffer,d 1975-u Linköpings universitet,Linköping University,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland4 aut0 (Swepub:liu)chrsj93 |
710 | 2 | a Linköping Universityb Avdelningen för neuro- och inflammationsvetenskap4 org |
773 | 0 | t Journal of Rheumatologyd : The Journal of Rheumatologyg 46:5, s. 492-500q 46:5<492-500x 0315-162Xx 1499-2752 |
856 | 4 | u http://dx.doi.org/10.3899/jrheum.180713x freey FULLTEXT |
856 | 4 | u https://www.jrheum.org/content/jrheum/46/5/492.full.pdf |
856 | 4 | u https://doi.org/10.3899/jrheum.180713y Fulltext |
856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:1318776/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://lup.lub.lu.se/record/75a564f3-2ebf-43ff-9b2b-49b0d3bb51e2 |
856 | 4 8 | u https://doi.org/10.3899/jrheum.180713 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-156906 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:140803375 |
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