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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004708naa a2200505 4500
001oai:lup.lub.lu.se:7fd08be3-041e-4222-96c7-8638e41333f9
003SwePub
008170823s2017 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/7fd08be3-041e-4222-96c7-8638e41333f92 URI
0247 a https://doi.org/10.1210/jc.2016-34292 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Billings, Liana K.u Harvard Medical School,Massachusetts General Hospital,NorthShore University HealthSystem4 aut
2451 0a Variation in maturity-onset diabetes of the young genes influence response to interventions for diabetes prevention
264 c 2017-04-27
264 1b The Endocrine Society,c 2017
300 a 12 s.
520 a Context: Variation in genes that cause maturity-onset diabetes of the young (MODY) has been associated with diabetes incidence and glycemic traits. Objectives: This study aimed to determine whether genetic variation in MODY genes leads to differential responses to insulin-sensitizing interventions. Design and Setting: This was a secondary analysis of a multicenter, randomized clinical trial, the Diabetes Prevention Program (DPP), involving 27 US academic institutions. We genotyped 22 missense and 221 common variants in the MODY-causing genes in the participants in the DPP. Participants and Interventions: The study included 2806 genotyped DPP participants randomized to receive intensive lifestyle intervention (n = 935), metformin (n = 927), or placebo (n = 944). Main Outcome Measures: Association of MODY genetic variants with diabetes incidence at a median of 3 years and measures of 1-year β-Cell function, insulinogenic index, and oral disposition index. Analyses were stratified by treatment group for significant single-nucleotide polymorphism 3 treatment interaction (Pint, 0.05). Sequence kernel association tests examined the association between an aggregate of rare missense variants and insulinogenic traits. Results: After 1 year, the minor allele of rs3212185 (HNF4A) was associated with improved β-Cell function in the metformin and lifestyle groups but not the placebo group; the minor allele of rs6719578 (NEUROD1) was associated with an increase in insulin secretion in the metformin group but not in the placebo and lifestyle groups. Conclusions: These results provide evidence that genetic variation among MODY genes may influence response to insulin-sensitizing interventions.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Jablonski, Kathleen Au George Washington University4 aut
7001 a Warner, A. Sofiau Massachusetts General Hospital4 aut
7001 a Cheng, Yu Chienu NorthShore University HealthSystem,University of Chicago4 aut
7001 a McAteer, Jarred B.u Massachusetts General Hospital4 aut
7001 a Tipton, Laurau George Washington University4 aut
7001 a Shuldiner, Alan R.4 aut
7001 a Ehrmann, David Au University of Chicago4 aut
7001 a Manning, Alisa K.u Broad Institute,Harvard Medical School,Massachusetts General Hospital4 aut
7001 a Dabelea, Danau Colorado School of Public Health4 aut
7001 a Franks, Paul W.u Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-plf
7001 a Kahn, Steven Eu University of Washington4 aut
7001 a Pollin, Toni Iu University of Maryland, Baltimore4 aut
7001 a Knowler, William Cu National Institute of Diabetes and Digestive and Kidney Diseases4 aut
7001 a Altshuler, Davidu Harvard Medical School,Broad Institute4 aut
7001 a Florez, Jose C.u Massachusetts General Hospital,Harvard Medical School,George Washington University,Broad Institute4 aut
7102 a Harvard Medical Schoolb Massachusetts General Hospital4 org
7102 a Diabetes Prevention Program Research Group
7730 t Journal of Clinical Endocrinology and Metabolismd : The Endocrine Societyg 102:8, s. 2678-2689q 102:8<2678-2689x 0021-972Xx 1945-7197
8564 u http://dx.doi.org/10.1210/jc.2016-3429x freey FULLTEXT
8564 u https://academic.oup.com/jcem/article-pdf/102/8/2678/19452572/jc.2016-3429.pdf
8564 8u https://lup.lub.lu.se/record/7fd08be3-041e-4222-96c7-8638e41333f9
8564 8u https://doi.org/10.1210/jc.2016-3429

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