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Sökning: onr:"swepub:oai:lup.lub.lu.se:82e26dcd-3702-4fd0-a2d3-dd463954e289" > Pooled analysis and...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003877naa a2200505 4500
001oai:lup.lub.lu.se:82e26dcd-3702-4fd0-a2d3-dd463954e289
003SwePub
008160401s2007 | |||||||||||000 ||eng|
024a https://lup.lub.lu.se/record/6512122 URI
024a https://doi.org/10.1093/aje/kwm0032 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a for2 swepub-publicationtype
072 7a ref2 swepub-contenttype
100a Kellen, Eliane4 aut
2451 0a Pooled analysis and meta-analysis of the glutathione S-transferase P1 lle 105Val polymorphism and bladder cancer: A HuGE-GSEC review
264 c 2007-04-02
264 1b Oxford University Press (OUP),c 2007
520 a The glutathione S-transferase P1 genotype (GSTP1) is involved in the inactivation of cigarette smoke carcinogens, and sequence variation in the gene may alter bladder cancer susceptibility. To examine the association between GSTP1lle 105Val and bladder cancer, the authors undertook a meta- and pooled analysis. Summary crude and adjusted odds ratios and corresponding 95% confidence intervals were pooled by using a random-effects model. In the meta-analysis (16 studies, 4,273 cases and 5,081 controls), the unadjusted summary odds ratios for GSTP1 lle/Val and Val/Val compared with GSTP1 lle/lle were 1.54 (95% confidence interval: 1.21,1.99; p < 0.001) and 2.17 (95% confidence interval: 1.27, 3.71; p = 0.005). The association appeared to be the strongest in Asian countries. When the analysis was limited to European descendents (nine studies), the summary odds ratio decreased (odds ratio = 1.24, 95% confidence interval: 1.00, 1.52) (Q = 17.50; p = 0.02). All relevant data previously contributed to the International Study on Genetic Susceptibility to Environmental Carcinogens were pooled (eight studies, 1,305 cases and 1,558 controls). The summary odds ratios were similar to the ones from the meta-analysis. Case-only analyses did not detect an interaction between the GSTP1 genotype and smoking status (never/ever). GSTP1 lle 105Val appears to be associated with a modest increase in the risk of bladder cancer.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
653 a urinary bladder neoplasms
653 a GSTP1
653 a meta-analysis
700a Hemelt, Marjolein4 aut
700a Broberg Palmgren, Karinu Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kgen-kbr
700a Golka, Klaus4 aut
700a Kristensen, Vessela Nedelcheva4 aut
700a Hung, Rayjean J.4 aut
700a Matullo, Giuseppe4 aut
700a Mittal, Rama D.4 aut
700a Porru, Stefano4 aut
700a Povey, Andrew4 aut
700a Schulz, Wolfgang A.4 aut
700a Shen, Jianhua4 aut
700a Buntinx, Frank4 aut
700a Zeegers, Maurice P.4 aut
700a Taioli, Emanuela4 aut
710a Avdelningen för arbets- och miljömedicinb Institutionen för laboratoriemedicin4 org
773t American Journal of Epidemiologyd : Oxford University Press (OUP)g 165:11, s. 1221-1230q 165:11<1221-1230x 0002-9262x 1476-6256
856u http://dx.doi.org/10.1093/aje/kwm003x freey FULLTEXT
856u https://academic.oup.com/aje/article-pdf/165/11/1221/204069/kwm003.pdf
8564 8u https://lup.lub.lu.se/record/651212
8564 8u https://doi.org/10.1093/aje/kwm003

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