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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04303naa a2200373 4500 | |
| 001 | oai:lup.lub.lu.se:8e59e21b-713d-49fb-8b14-1ac8a53800e5 | |
| 003 | SwePub | |
| 008 | 160401s2001 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/11201082 URI |
| 024 | 7 | a https://doi.org/10.1038/modpathol.38803082 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Broberg Palmgren, Karinu Lund University,Lunds universitet,Institutionen för laboratoriemedicin,Medicinska fakulteten,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kgen-kbr |
| 245 | 1 0 | a The tumor-associated gene HMGIC is expressed in normal and osteoarthritis-affected synovia |
| 264 | 1 | b Elsevier BV,c 2001 |
| 520 | a Chromosomal rearrangements involving chromosome bands 12q13-15 are very frequent findings in benign solid tumors, and recently, the primary molecular target for these aberrations was identified as the gene HMGIC. However, mutations in this gene have also been observed in nonneoplastic tissues. In a previous study, we reported breakpoints within HMGIC of synovia affected by osteoarthritis (OA) in two cases with 12q15 aberrations. To analyze further the role of HMGIC in this disease, we have performed cytogenetic, fluorescent in situ hybridization (FISH), RNA, and protein expression analyses on synovial samples from patients with OA and individuals without signs of the disorder. Cytogenetic analysis of short-term cultured cells revealed clonal 12q13-15 aberrations in 2/36 cases of OA synovia and no rearrangement in any of the five controls. With FISH analysis, it was shown that the chromosomal breakpoints in the two aberrant cases were located outside the HMGIC locus. In contrast, at RNA and protein expression analyses, OA-affected as well as normal synovia displayed transcription and translation of the gene. We also analyzed whether immunoreactivity for HMGIC was associated with the proliferation-specific antigen Ki-67, but no correlation between the staining patterns of these proteins was observed. From the results of the present study, it is evident that expression of HMGIC cannot simply be considered a sign of neoplasia or an effect of proliferation. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Ortopedi0 (SwePub)302112 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Orthopaedics0 (SwePub)302112 hsv//eng |
| 700 | 1 | a Tallini, Giovanni4 aut |
| 700 | 1 | a Höglund, Mattiasu Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kgen-mho |
| 700 | 1 | a Lindstrand, Andersu Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)ort-ali |
| 700 | 1 | a Toksvig-Larsen, Sörenu Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)ort-stl |
| 700 | 1 | a Mertens, Fredriku Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kgen-fme |
| 710 | 2 | a Institutionen för laboratoriemedicinb Medicinska fakulteten4 org |
| 773 | 0 | t Modern Pathologyd : Elsevier BVg 14:4, s. 311-317q 14:4<311-317x 1530-0285x 0893-3952 |
| 856 | 4 | u http://dx.doi.org/10.1038/modpathol.3880308y FULLTEXT |
| 856 | 4 | u https://www.nature.com/articles/3880308.pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1120108 |
| 856 | 4 8 | u https://doi.org/10.1038/modpathol.3880308 |
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