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Search: onr:"swepub:oai:lup.lub.lu.se:909cec4d-5d56-4076-9194-d241970ce185" > Evaluating the DICE...

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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004945naa a2200469 4500
001oai:lup.lub.lu.se:909cec4d-5d56-4076-9194-d241970ce185
003SwePub
008230112s2022 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/909cec4d-5d56-4076-9194-d241970ce1852 URI
0247 a https://doi.org/10.1002/alz.0622922 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Eikelboom, Willem S.u Erasmus University Medical Center4 aut
2451 0a Evaluating the DICE method to improve early recognition and treatment of neuropsychiatric symptoms in early Alzheimer’s disease
264 c 2022-12-20
264 1b Wiley,c 2022
520 a Background: While neuropsychiatric symptoms (NPS) are common in early Alzheimer’s disease (AD), they are currently underdiagnosed and undertreated in the memory clinic. Therefore, we evaluated the effectiveness of the Describe, Investigate, Create, Evaluate (DICE™) approach to structure and standardize the care for NPS in AD in the memory clinic. Method: A total of 60 community-dwelling patients with MCI, AD dementia, or AD/VaD dementia were enrolled with their caregivers in two waves (Table-1). The first wave (n = 36) received care as usual and served as a control group, while the second wave of patients (n = 24, of which n = 20 have currently completed the study) underwent the DICE method. We applied the DICE method during two visits in which NPS were assessed, underlying causes were examined, and patients and caregivers were instructed on management strategies to deal with NPS, which were evaluated after one month. Outcomes were assessed after three and six months. Primary outcomes were quality of life of patients (QoL-AD) and caregivers (Carerqol-7D). Secondary outcomes included caregiver burden (Perseverance time), NPS prevalence and severity (NPI-Q & BEHAVE-AD), NPS-related distress (NPI-Q), competence managing NPS (additional NPI-Q item), and psychotropic drug use. We used linear mixed models to examine differences in outcomes at group-level and reliable change index to examine which participants in the intervention group showed reliable improvement in the primary outcomes. Result: We found no significant differences between the two groups in change in quality of life or any of the secondary outcomes (all p>0.05, Table-2). A proportion of the intervention group showed reliable improvement in quality of life of patients (n = 6/20) and caregivers (n = 7/20). At baseline, these patients tended to show higher NPS burden and their caregivers reported more NPS-related distress and lower feelings of competence while managing NPS compared to participants that did no show reliable improvement. Conclusion: This Stage 2 efficacy study shows no benefits of the DICE method on in early AD at group-level, but suggest that particular participants might benefit from this approach. Data will be re-analyzed when all intervention group participants have completed the study and will be extended with qualitative data investigating NPS-related knowledge and management styles of participants.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
7001 a van den Berg, Estheru Erasmus University Medical Center4 aut
7001 a Raso, Francesco U.S.Mattaceu Erasmus University Medical Center4 aut
7001 a van Bruchem-Visser, Rozemarijn L.u Erasmus University Medical Center4 aut
7001 a Goudzwaard, Jeannette A.u Erasmus University Medical Center4 aut
7001 a de Jong, Frank Janu Erasmus University Medical Center4 aut
7001 a den Heijer, Tom4 aut
7001 a Driesen, Jan J.M.4 aut
7001 a Vroegindeweij, Lilian J.H.M.4 aut
7001 a Thomeer, Elsbeth C.4 aut
7001 a Hoogers, Susanne E.4 aut
7001 a Singleton, Ellen H.u Vrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam4 aut
7001 a van Swieten, John C.u Erasmus University Medical Center4 aut
7001 a Ossenkoppele, Riku Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Vrije Universiteit Amsterdam4 aut0 (Swepub:lu)ri1513os
7001 a Coesmans, Michielu Erasmus University Medical Center4 aut
7001 a Papma, Janne M.u Erasmus University Medical Center4 aut
7102 a Erasmus University Medical Centerb Vrije Universiteit Amsterdam4 org
7730 t Alzheimer's and Dementiad : Wileyg 18:S8q 18:S8x 1552-5260x 1552-5279
8564 u http://dx.doi.org/10.1002/alz.062292y FULLTEXT
8564 8u https://lup.lub.lu.se/record/909cec4d-5d56-4076-9194-d241970ce185
8564 8u https://doi.org/10.1002/alz.062292

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