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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04183naa a2200577 4500 | |
| 001 | oai:lup.lub.lu.se:917e9df2-c39e-4b86-88d5-27fdc1492924 | |
| 003 | SwePub | |
| 008 | 160401s2006 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/4163362 URI |
| 024 | 7 | a https://doi.org/10.1111/j.1538-7836.2006.01847.x2 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Tosetto, A4 aut |
| 245 | 1 0 | a A quantitative analysis of bleeding symptoms in type 1 von Willebrand disease: results from a multicenter European study (MCMDM-1 VWD) |
| 264 | 1 | b Elsevier BV,c 2006 |
| 520 | a Background: A quantitative description of bleeding symptoms in type 1 von Willebrand disease (VWD) has never been reported. Objectives: The aim was to quantitatively evaluate the severity of bleeding symptoms in type 1 VWD and its correlation with clinical and laboratory features. Patients and methods: Bleeding symptoms were retrospectively recorded in a European cohort of VWD type 1 families, and for each subject a quantitative bleeding score (BS) was obtained together with phenotypic tests. Results: A total of 712 subjects belonging to 144 families and 195 controls were available for analysis. The BS was higher in index cases than in affected family members (BS 9 vs. 5, P < 0.0001) and in unaffected family members than in controls (BS 0 vs. -1, P < 0.0001). There was no effect of ABO blood group. BS showed a strong significant inverse relation with either von Willebrand ristocetin cofactor (VWF:RCo), von Willebrand antigen (VWF:Ag) or factor VIII procoagulant activity (FVIII:C) measured at time of enrollment, even after adjustment for age, sex and blood group (P < 0.001 for all the four upper quintiles of BS vs. the first quintile, for either VWF:RCo, VWF:Ag or FVIII:C). Higher BS was related with increasing likelihood of VWD, and a mucocutaneous BS (computed from spontaneous, mucocutaneous symptoms) was strongly associated with bleeding after surgery or tooth extraction. Conclusions: Quantitative analysis of bleeding symptoms is potentially useful for a more accurate diagnosis of type 1 VWD and to develop guidelines for its optimal treatment. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
| 653 | a von Willebrand disease diagnosis | |
| 653 | a von Willebrand disease | |
| 653 | a bleeding score | |
| 653 | a inherited bleeding disorders | |
| 700 | 1 | a Rodeghiero, F4 aut |
| 700 | 1 | a Castaman, G4 aut |
| 700 | 1 | a Goodeve, A4 aut |
| 700 | 1 | a Federici, AB4 aut |
| 700 | 1 | a Batlle, J4 aut |
| 700 | 1 | a Meyer, D4 aut |
| 700 | 1 | a Fressinaud, E4 aut |
| 700 | 1 | a Mazurier, C4 aut |
| 700 | 1 | a Goudemand, J4 aut |
| 700 | 1 | a Eikenboom, J4 aut |
| 700 | 1 | a Schneppenheim, R4 aut |
| 700 | 1 | a Budde, U4 aut |
| 700 | 1 | a Ingerslev, J4 aut |
| 700 | 1 | a Vorlova, Z4 aut |
| 700 | 1 | a Habart, D4 aut |
| 700 | 1 | a Holmberg, Larsu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pedi-lho |
| 700 | 1 | a Lethagen, Stefanu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine4 aut0 (Swepub:lu)medf-sle |
| 700 | 1 | a Pasi, J4 aut |
| 700 | 1 | a Hill, F4 aut |
| 700 | 1 | a Peake, I4 aut |
| 710 | 2 | a Pediatrik, Lundb Sektion V4 org |
| 773 | 0 | t Journal of Thrombosis and Haemostasisd : Elsevier BVg 4:4, s. 766-773q 4:4<766-773x 1538-7933x 1538-7836 |
| 856 | 4 | u http://dx.doi.org/10.1111/j.1538-7836.2006.01847.xy FULLTEXT |
| 856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1538-7836.2006.01847.x |
| 856 | 4 8 | u https://lup.lub.lu.se/record/416336 |
| 856 | 4 8 | u https://doi.org/10.1111/j.1538-7836.2006.01847.x |
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- Tosetto, A
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- Meyer, D
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