Sökning: onr:"swepub:oai:lup.lub.lu.se:95dd2187-b78c-4348-9623-311ac935e33e" > Genetic variants as...
Fältnamn | Indikatorer | Metadata |
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000 | 03840naa a2200421 4500 | |
001 | oai:lup.lub.lu.se:95dd2187-b78c-4348-9623-311ac935e33e | |
003 | SwePub | |
008 | 231110s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/95dd2187-b78c-4348-9623-311ac935e33e2 URI |
024 | 7 | a https://doi.org/10.1111/obr.136262 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a for2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a van der Meer, Rienekeu Academic Medical Center of University of Amsterdam (AMC)4 aut |
245 | 1 0 | a Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery : A systematic review |
264 | 1 | c 2023 |
520 | a The extent to which genetic variations contribute to interindividual differences in weight loss and metabolic outcomes after bariatric surgery is unknown. Identifying genetic variants that impact surgery outcomes may contribute to clinical decision making. This review evaluates current evidence addressing the association of genetic variants with weight loss and changes in metabolic parameters after bariatric surgery. A search was conducted using Medline, Embase, Scopus, Web of Science, and Cochrane Library. Fifty-two eligible studies were identified. Single nucleotide polymorphisms (SNPs) at ADIPOQ (rs226729, rs1501299, rs3774261, and rs17300539) showed a positive association with postoperative change in measures of glucose homeostasis and lipid profiles (n = 4), but not with weight loss after surgery (n = 6). SNPs at FTO (rs11075986, rs16952482, rs8050136, rs9939609, rs9930506, and rs16945088) (n = 10) and MC4R (rs11152213, rs476828, rs2229616, rs9947255, rs17773430, rs5282087, and rs17782313) (n = 9) were inconsistently associated with weight loss and metabolic improvement. Four studies examining the UCP2 SNP rs660339 reported associations with postsurgical weight loss. In summary, there is limited evidence supporting a role for specific genetic variants in surgical outcomes after bariatric surgery. Most studies have adopted a candidate gene approach, limiting the scope for discovery, suggesting that the absence of compelling evidence is not evidence of absence. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
653 | a bariatric surgery | |
653 | a genetic variants | |
653 | a SNPs | |
653 | a surgery outcomes | |
700 | 1 | a Mohamed, Siham A.u Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)si5462ab |
700 | 1 | a Monpellier, Valerie M.u Obesity Clinic Hoogeveen4 aut |
700 | 1 | a Liem, Ronald S.L.u Obesity Clinic Hoogeveen4 aut |
700 | 1 | a Hazebroek, Eric J.u Rijnstate Hospital4 aut |
700 | 1 | a Franks, Paul W.u Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-plf |
700 | 1 | a Frayling, Timothy M.u University of Exeter4 aut |
700 | 1 | a Janssen, Ignace M.C.4 aut |
700 | 1 | a Serlie, Mireille J.u Yale University,Academic Medical Center of University of Amsterdam (AMC)4 aut |
710 | 2 | a Academic Medical Center of University of Amsterdam (AMC)b Genetisk och molekylär epidemiologi4 org |
773 | 0 | t Obesity Reviewsg 24:12q 24:12x 1467-7881 |
856 | 4 | u http://dx.doi.org/10.1111/obr.13626x freey FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/95dd2187-b78c-4348-9623-311ac935e33e |
856 | 4 8 | u https://doi.org/10.1111/obr.13626 |
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