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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03550naa a2200349 4500 | |
| 001 | oai:lup.lub.lu.se:97402038-ea39-4e2f-be17-28e29e6d3ae0 | |
| 003 | SwePub | |
| 008 | 160401s2014 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:128770016 | |
| 024 | 7 | a https://lup.lub.lu.se/record/43839272 URI |
| 024 | 7 | a https://doi.org/10.1016/j.smim.2014.02.0032 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1287700162 URI |
| 040 | a (SwePub)lud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a for2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Cichocki, Franku University of Minnesota4 aut |
| 245 | 1 0 | a NK cell development and function - Plasticity and redundancy unleashed. |
| 264 | 1 | b Elsevier BV,c 2014 |
| 520 | a Bone marrow-derived natural killer (NK) cells constitute the major subset of cytotoxic lymphocytes in peripheral blood. They provide innate defense against intracellular infection or malignancy and contribute to immune homeostasis. Large numbers of NK cells are also present in tissues, including the liver and uterus, where they can mediate immunosurveillance but also play important roles in tissue remodeling and vascularization. Here, we review the pathways involved in NK cell lineage commitment and differentiation, discussing relationships to other lymphocyte populations and highlighting genetic determinants. Characterizing NK cells from distinct tissues and during infections have revealed subset specializations, reflecting inherent cellular plasticity. In this context, we discuss how different environmental and inflammatory stimuli may shape NK cells. Particular emphasis is placed on genes identified as being critical for NK cell development, differentiation, and function from studies of model organisms or associations with disease. Such studies are also revealing important cellular redundancies. Here, we provide a view of the genetic framework constraining NK cell development and function, pinpointing molecules required for these processes but also underscoring plasticity and redundancy that may underlie robust immunological function. With this view, built in redundancy may highlight the importance of NK cells to immunity. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
| 700 | 1 | a Sitnicka Quinn, Ewau Lund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Lymfocytutveckling och reglering,Forskargrupper vid Lunds universitet,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine,Lymphoid Development and Regulation,Lund University Research Groups4 aut0 (Swepub:lu)molm-esi |
| 700 | 1 | a Bryceson, Yenan Tu Karolinska Institutet4 aut |
| 710 | 2 | a University of Minnesotab Avdelningen för molekylär hematologi4 org |
| 773 | 0 | t Seminars in Immunologyd : Elsevier BVg 26:2, s. 114-126q 26:2<114-126x 1096-3618x 1044-5323 |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/24594002?dopt=Abstracty FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1016/j.smim.2014.02.003y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/4383927 |
| 856 | 4 8 | u https://doi.org/10.1016/j.smim.2014.02.003 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:128770016 |
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