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Sökning: onr:"swepub:oai:lup.lub.lu.se:9b88ec94-2d70-4cb9-be62-3af044767dd1" > Assessment of Brain...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005825naa a2200721 4500
001oai:lup.lub.lu.se:9b88ec94-2d70-4cb9-be62-3af044767dd1
003SwePub
008231019s2019 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/9b88ec94-2d70-4cb9-be62-3af044767dd12 URI
0247 a https://doi.org/10.1016/j.jpeds.2018.12.0622 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Cizmeci, Mehmet Nu University Medical Center Utrecht4 aut
2451 0a Assessment of Brain Injury and Brain Volumes after Posthemorrhagic Ventricular Dilatation : A Nested Substudy of the Randomized Controlled ELVIS Trial
264 1b Elsevier BV,c 2019
520 a OBJECTIVE: To compare the effect of early and late intervention for posthemorrhagic ventricular dilatation on additional brain injury and ventricular volume using term-equivalent age-MRI.STUDY DESIGN: In the Early vs Late Ventricular Intervention Study (ELVIS) trial, 126 preterm infants ≤34 weeks of gestation with posthemorrhagic ventricular dilatation were randomized to low-threshold (ventricular index >p97 and anterior horn width >6 mm) or high-threshold (ventricular index >p97 + 4 mm and anterior horn width >10 mm) groups. In 88 of those (80%) with a term-equivalent age-MRI, the Kidokoro Global Brain Abnormality Score and the frontal and occipital horn ratio were measured. Automatic segmentation was used for volumetric analysis.RESULTS: The total Kidokoro score of the infants in the low-threshold group (n = 44) was lower than in the high-threshold group (n = 44; median, 8 [IQR, 5-12] vs median 12 [IQR, 9-17], respectively; P < .001). More infants in the low-threshold group had a normal or mildly increased score vs more infants in the high-threshold group with a moderately or severely increased score (46% vs 11% and 89% vs 54%, respectively; P = .002). The frontal and occipital horn ratio was lower in the low-threshold group (median, 0.42 [IQR, 0.34-0.63]) than the high-threshold group (median 0.48 [IQR, 0.37-0.68], respectively; P = .001). Ventricular cerebrospinal fluid volumes could be calculated in 47 infants and were smaller in the low-threshold group (P = .03).CONCLUSIONS: More brain injury and larger ventricular volumes were demonstrated in the high vs the low-threshold group. These results support the positive effects of early intervention for posthemorrhagic ventricular dilatation.TRIAL REGISTRATION: ISRCTN43171322.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
653 a Brain/diagnostic imaging
653 a Brain Injuries/diagnostic imaging
653 a Cerebral Hemorrhage/diagnostic imaging
653 a Cerebral Ventricles/diagnostic imaging
653 a Cerebrospinal Fluid
653 a Cerebrospinal Fluid Shunts
653 a Dilatation
653 a Female
653 a Humans
653 a Hydrocephalus/diagnostic imaging
653 a Infant, Newborn
653 a Infant, Premature
653 a Infant, Premature, Diseases/diagnostic imaging
653 a Intracranial Hemorrhages/diagnostic imaging
653 a Magnetic Resonance Imaging
653 a Male
653 a White Matter/diagnostic imaging
7001 a Khalili, Nadiehu University Medical Center Utrecht4 aut
7001 a Claessens, Nathalie H Pu University Medical Center Utrecht4 aut
7001 a Groenendaal, Florisu University Medical Center Utrecht4 aut
7001 a Liem, Kian Du Radboud University Medical Center4 aut
7001 a Heep, Axelu University of Bristol4 aut
7001 a Benavente-Fernández, Isabelu Puerta del Mar University Hospital4 aut
7001 a van Straaten, Henrica L Mu Isala Women and Children's Hospital4 aut
7001 a van Wezel-Meijler, Gerdau Leiden University Medical Centre4 aut
7001 a Steggerda, Sylke Ju Leiden University Medical Centre4 aut
7001 a Dudink, Jeroenu University Medical Center Utrecht4 aut
7001 a Išgum, Ivanau University Medical Center Utrecht4 aut
7001 a Whitelaw, Andrewu University of Bristol4 aut
7001 a Benders, Manon J N Lu University Medical Center Utrecht4 aut
7001 a de Vries, Linda Su University Medical Center Utrecht4 aut
7001 a Ley, Davidu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neonatalogi,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neonatology,Lund University Research Groups4 cre0 (Swepub:lu)pedi-dle
7001 a Fellman, Vinetau Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 cre0 (Swepub:lu)pedi-vfe
7102 a University Medical Center Utrechtb Radboud University Medical Center4 org
7102 a ELVIS study group
7730 t Journal of Pediatricsd : Elsevier BVg 208, s. 2-197q 208<2-197x 1097-6833x 0022-3476
8564 u http://dx.doi.org/10.1016/j.jpeds.2018.12.062y FULLTEXT
8564 u https://research-information.bris.ac.uk/ws/files/205028352/Manuscript_R10_1_.pdf
8564 8u https://lup.lub.lu.se/record/9b88ec94-2d70-4cb9-be62-3af044767dd1
8564 8u https://doi.org/10.1016/j.jpeds.2018.12.062

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