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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003357naa a2200409 4500
001oai:lup.lub.lu.se:9d2f9bbe-6e90-4c6d-9e8a-51349acf6004
003SwePub
008160401s2003 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/8920922 URI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Iversen, AKN4 aut
2451 0a Limited protective effect of the CCR5 Delta 32/CCR5 Delta 32 genotype on human immunodeficiency virus infection incidence in a cohort of patients with hemophilia and selection for genotypic X4 virus
264 1c 2003
520 a The relationship among CCR5 genotype, cytomegalovirus infection, and disease progression and death was studied among 159 human immunodeficiency virus (HIV)-infected patients with hemophilia. One patient (0.6%) had the CCR5Delta32/CCR5Delta32 genotype (which occurs in similar to2% of the Scandinavian population) and a rapid disease course. His HIV V3 region contained genotypic features attributable to X4 virus and resembled functionally verified X4 virus and virus from patients treated with a CD4 cell-stimulating drug, tucaresol. Age-related differences in disease progression rate and survival time were seen for CCR5/CCR5 patients. Surprisingly, no protective effect of the CCR5/CCR5Delta32 genotype on disease progression or survival was seen for children but was evident for adults. Age group-related immunologic differences might explain this variation, and transmission route and/or viral phenotype variation within donor virus may be related to the limited protection of the CCR5Delta32/ CCR5Delta32 genotype. Sequence comparisons indicate that X4 virus can be selected in vivo due to either absence of CCR5 receptors or relative increase of CXCR4 receptors.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
7001 a Christiansen, CB4 aut
7001 a Attermann, J4 aut
7001 a Eugen-Olsen, J4 aut
7001 a Schulman, S4 aut
7001 a Berntorp, Eriku Lund University,Lunds universitet,Klinisk koagulationsmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Coagulation, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)medf-ebe
7001 a Ingerslev, J4 aut
7001 a Fugger, L4 aut
7001 a Scheibel, E4 aut
7001 a Tengborn, Lilianu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk koagulationsmedicin, Malmö,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Coagulation, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)medf-lte
7001 a Gerstoft, J4 aut
7001 a Dickmeiss, E4 aut
7001 a Svejgaard, A4 aut
7001 a Skinhoj, P4 aut
7102 a Klinisk koagulationsmedicin, Malmöb Forskargrupper vid Lunds universitet4 org
7730 t Journal of Infectious Diseasesg 187:2, s. 215-225q 187:2<215-225x 1537-6613
8564 u http://ucp.uchicago.edu/JID/journal/issues/v187n2/020881/brief/020881.abstract.htmly FULLTEXT
8564 8u https://lup.lub.lu.se/record/892092

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