onr:"swepub:oai:lup.lub.lu.se:9e4f1de5-f578-4163-865b-9d9336693ad1"
Search: onr:"swepub:oai:lup.lub.lu.se:9e4f1de5-f578-4163-865b-9d9336693ad1" > Epstein-Barr virus-...
- 1 of 1
- Previous record
- Next record
- To hitlist
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03554naa a2200397 4500 | |
| 001 | oai:lup.lub.lu.se:9e4f1de5-f578-4163-865b-9d9336693ad1 | |
| 003 | SwePub | |
| 008 | 160420s1992 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/9e4f1de5-f578-4163-865b-9d9336693ad12 URI |
| 024 | 7 | a https://doi.org/10.1016/0165-2478(92)90217-C2 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Ohlin, M.u Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)immt-moh |
| 245 | 1 0 | a Epstein-Barr virus-induced transformation of human B lymphocytes : the effect of l-leucyl-l-leucine methyl ester on inhibitory T cell populations |
| 264 | 1 | c 1992 |
| 300 | a 8 s. | |
| 520 | a Epstein-Barr virus-mediated transformation of human B lymphocytes is inhibited by human T lymphocytes as well as by interferon-γ. Removal of the inhibitory cell populations is essential in order to achieve successful transformation in vitro. Cells with the capacity to inhibit outgrowth of lymphoblastoid cell lines can be removed by pretreatment of peripheral blood mononuclear cells with l-leucyl-l-leucine methyl ester. This treatment eliminates monocytes, NK-cells and a CD8+ T cell subpopulation. We now show that such treatment also has toxic effects on other human T cell populations. In addition, CD4+ and/or CD8+ lymphocytes are demonstrated to contain effector cell activities which inhibit outgrowth of EBV-transformed B cells. This inhibitory activity is abolished after treatment of peripheral blood mononuclear cells or purified CD4+ T cells with l-leucyl-l-leucine methyl ester. No evidence was found for a selective toxicity against any subset within the CD4+ or CD8+ T cell populations. However, the capacity of the treated cells, both peripheral blood mononuclear cells and purified CD4+ T lymphocytes, to produce mRNA encoding IFN-γ, a protein previously shown to downregulate outgrowth of EBV-transformed B cells, was selectively impaired. The results obtained suggest a role for CD4+ T cells to inhibit EBV-induced transformation of B cells. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
| 653 | a B lymphocyte | |
| 653 | a Epstein-Barr virus | |
| 653 | a Interferon | |
| 653 | a l-Leucyl-l-leucine methyl ester | |
| 653 | a T lymphocyte | |
| 653 | a Transformation | |
| 700 | 1 | a Kristensson, K.u BioInvent Therapeutic AB4 aut |
| 700 | 1 | a Carlsson, R.u BioInvent Therapeutic AB4 aut0 (Swepub:lu)extLU-1274 |
| 700 | 1 | a Borrebaeck, C. A Ku Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)immt-cbo |
| 710 | 2 | a Institutionen för immunteknologib Institutioner vid LTH4 org |
| 773 | 0 | t Immunology Lettersg 34:3, s. 221-228q 34:3<221-228x 0165-2478 |
| 856 | 4 | u http://dx.doi.org/10.1016/0165-2478(92)90217-Cy FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/9e4f1de5-f578-4163-865b-9d9336693ad1 |
| 856 | 4 8 | u https://doi.org/10.1016/0165-2478(92)90217-C |
Find in a library
- Immunology Letters (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Ohlin, M.
- Kristensson, K.
- Carlsson, R.
- Borrebaeck, C. A ...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Immunology in th ...
- Articles in the publication
- Immunology Lette ...
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
