Sökning: onr:"swepub:oai:lup.lub.lu.se:9e77d100-ffa9-4ff5-960a-8a24c2a7f702" > Prolonged labour as...
Fältnamn | Indikatorer | Metadata |
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000 | 04167naa a2200409 4500 | |
001 | oai:lup.lub.lu.se:9e77d100-ffa9-4ff5-960a-8a24c2a7f702 | |
003 | SwePub | |
008 | 160401s2006 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:1940121 | |
024 | 7 | a https://lup.lub.lu.se/record/4058302 URI |
024 | 7 | a https://doi.org/10.1186/1477-7827-4-242 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19401212 URI |
040 | a (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Cluff, AH4 aut |
245 | 1 0 | a Prolonged labour associated with lower expression of syndecan 3 and connexin 43 in human uterine tissue |
264 | c 2006-05-04 | |
264 | 1 | b Springer Science and Business Media LLC,c 2006 |
520 | a Background: Prolonged labour is associated with greater morbidity and mortality for mother and child. Connexin 43 is a major myometrial gap junction protein found in human myometrium. Syndecan 3 seems to prevail in the human uterus among heparan sulphate proteoglycans, showing the most significant increase during labour. The aims of the present study were to investigate syndecan 3 and connexin 43 mRNA expressions and protein distributions in human uterine tissue during normal and prolonged labour. Methods: Uterine isthmic biopsies were collected from non-pregnant (n = 7), term pregnant women not in labour (n = 14), in normal labour (n = 7) and in prolonged labour (n = 7). mRNA levels of syndecan 3 and connexin 43 were determined by real time RT-PCR. The localization and expression were demonstrated by immunohistochemistry and confocal microscopy. Results: In women with prolonged labour, the mRNA expressions of syndecan 3 and Connexin 43 were considerably lower than the expression level at normal labour (p < 0.05). In term-pregnant tissue, the expression of syndecan 3 and connexin 43 did not differ significantly compared to nonpregnant and normal labour. The immunoreactivity of syndecan 3 was strong at normal labour, in contrast to prolonged labour, where both a weaker expression and an irregular distribution were detected. The immunoreactivity of connexin 43 increased until term and further stronger staining occurred at normal labour. At prolonged labour, the immunoreactivity was weaker and more unevenly distributed. At labour, a co-localization of syndecan 3 and connexin 43 could be demonstrated in the smooth muscle by confocal microscopy. Conclusion: The high expression of syndecan 3 and connexin 43 and their co-localization to the smooth muscle bundles during normal labour, together with the significant reduction in prolonged labour, may indicate a role for these proteins in the co-ordination of myometrial contractility. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
700 | 1 | a Bystrom, Bu Karolinska Institutet4 aut |
700 | 1 | a Klimaviciute, Au Karolinska Institutet4 aut |
700 | 1 | a Dahlqvist, Camillau Lund University,Lunds universitet,Matrixbiologi,Forskargrupper vid Lunds universitet,Matrix Biology,Lund University Research Groups4 aut0 (Swepub:lu)medk-cda |
700 | 1 | a Cebers, G4 aut |
700 | 1 | a Malmström, Andersu Lund University,Lunds universitet,Matrixbiologi,Forskargrupper vid Lunds universitet,Matrix Biology,Lund University Research Groups4 aut0 (Swepub:lu)medk-ama |
700 | 1 | a Ekman-Ordeberg, Gu Karolinska Institutet4 aut |
710 | 2 | a Karolinska Institutetb Matrixbiologi4 org |
773 | 0 | t Reproductive Biology and Endocrinologyd : Springer Science and Business Media LLCg 4q 4x 1477-7827 |
856 | 4 | u http://dx.doi.org/10.1186/1477-7827-4-24x freey FULLTEXT |
856 | 4 | u https://rbej.biomedcentral.com/track/pdf/10.1186/1477-7827-4-24 |
856 | 4 8 | u https://lup.lub.lu.se/record/405830 |
856 | 4 8 | u https://doi.org/10.1186/1477-7827-4-24 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1940121 |
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