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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05572naa a2200385 4500 | |
| 001 | oai:lup.lub.lu.se:9f3de318-d931-49cb-81d9-10415943eba7 | |
| 003 | SwePub | |
| 008 | 160401s2013 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/33469282 URI |
| 024 | 7 | a https://doi.org/10.1007/s00394-012-0479-12 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Andersson, Kristina Eu Lund University,Lunds universitet,Cellulär biomekanik,Forskargrupper vid Lunds universitet,Kärlfysiologi,Cellular Biomechanics,Lund University Research Groups,Vascular Physiology4 aut0 (Swepub:lu)mphy-kar |
| 245 | 1 0 | a Diverse effects of oats on cholesterol metabolism in C57BL/6 mice correlate with expression of hepatic bile acid-producing enzymes. |
| 264 | c 2012-12-21 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2013 |
| 520 | a PURPOSE: We previously reported that two substrains of C57BL/6 mice respond differently to oats with respect to reduction in plasma cholesterol. Analysis of this difference might offer clues to mechanisms behind the cholesterol-lowering effect of oats. Here, we address the possible roles of hepatic steroid metabolism and the intestinal microbiota in this respect. METHODS: Female C57BL/6 mice were fed an atherogenic diet with oat bran (27 %) or control fibres for 4 weeks. RESULTS: C57BL/6 NCrl mice responded to oat bran with 19 ± 1 % (P < 0.001) lower plasma cholesterol, 40 ± 5 % (P < 0.01) higher excretion of bile acids and increased expression of the bile acid-producing hepatic enzymes CYP7A1 and CYP8B1, but none of these effects were found in C57BL/6JBomTac mice. However, on control diet, C57BL/6JBomTac had tenfold higher expression of CYP7A1 and levels of hepatic cholesterol esters than C57BL/6NCrl mice. Plasma levels of fructosamine indicated improved glycemic control by oat bran in C57BL/6NCrl but not in C57BL/6JBomTac. C57BL/6JBomTac had higher intestinal microbiota diversity, but lower numbers of Enterobacteriaceae, Akkermansia and Bacteroides Fragilis than C57BL/6NCrl mice. Oat bran increased bacterial numbers in both substrains. Microbiota diversity was reduced by oats in C57BL/6JBomTac, but unaffected in C57BL/6NCrl. CONCLUSIONS: Our data do not support a connection between altered microbiota diversity and reduced plasma cholesterol, but the bacterial composition in the intestine may influence the effects of added fibres. The cholesterol-lowering properties of oats involve increased production of bile acids via the classical pathway with up-regulation of CYP7A1 and CYP8B1. Altered cholesterol or bile acid metabolism may interfere with the potential of oats to reduce plasma cholesterol. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng |
| 700 | 1 | a Axling, Ulrikau Lund University,Lunds universitet,Molekylär endokrinologi,Forskargrupper vid Lunds universitet,Molecular Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)med-uka |
| 700 | 1 | a Xu, Jieu Lund University,Lunds universitet,Avdelningen för livsmedel och läkemedel,Institutionen för processteknik och tillämpad biovetenskap,Institutioner vid LTH,Lunds Tekniska Högskola,Division of Food and Pharma,Department of Process and Life Science Engineering,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)appl-jxu |
| 700 | 1 | a Swärd, Karlu Lund University,Lunds universitet,Cellulär biomekanik,Forskargrupper vid Lunds universitet,Kärlfysiologi,Cellular Biomechanics,Lund University Research Groups,Vascular Physiology4 aut0 (Swepub:lu)mphy-ksw |
| 700 | 1 | a Ahrné, Sivu Lund University,Lunds universitet,Livsmedelsteknik,Avdelningen för livsmedel och läkemedel,Institutionen för processteknik och tillämpad biovetenskap,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Food Technology, Engineering and Nutrition,Division of Food and Pharma,Department of Process and Life Science Engineering,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)livt-sah |
| 700 | 1 | a Molin, Göranu Lund University,Lunds universitet,Livsmedelsteknik,Avdelningen för livsmedel och läkemedel,Institutionen för processteknik och tillämpad biovetenskap,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Food Technology, Engineering and Nutrition,Division of Food and Pharma,Department of Process and Life Science Engineering,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)livt-gmo |
| 700 | 1 | a Holm, Ceciliau Lund University,Lunds universitet,Molekylär endokrinologi,Forskargrupper vid Lunds universitet,Molecular Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)medk-cho |
| 700 | 1 | a Hellstrand, Peru Lund University,Lunds universitet,Kärlfysiologi,Forskargrupper vid Lunds universitet,Vascular Physiology,Lund University Research Groups4 aut0 (Swepub:lu)mphy-phe |
| 710 | 2 | a Cellulär biomekanikb Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t European Journal of Nutritiond : Springer Science and Business Media LLCg 52:7, s. 1755-1769q 52:7<1755-1769x 1436-6215x 1436-6207 |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/23262749?dopt=Abstracty FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1007/s00394-012-0479-1y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/3346928 |
| 856 | 4 8 | u https://doi.org/10.1007/s00394-012-0479-1 |
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