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Human postprandial ...
Human postprandial responses to food and potential for precision nutrition
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- Berry, Sarah E. (author)
- King's College London
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- Valdes, Ana M. (author)
- University of Nottingham
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- Drew, David A. (author)
- Massachusetts General Hospital
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- Asnicar, Francesco (author)
- University of Trento
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- Mazidi, Mohsen (author)
- King's College London
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- Wolf, Jonathan (author)
- Zoe Global Limited
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- Capdevila, Joan (author)
- Zoe Global Limited
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- Hadjigeorgiou, George (author)
- Zoe Global Limited
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- Davies, Richard (author)
- Zoe Global Limited
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- Al Khatib, Haya (author)
- King's College London
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- Bonnett, Christopher (author)
- Zoe Global Limited
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- Ganesh, Sajaysurya (author)
- Zoe Global Limited
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- Bakker, Elco (author)
- Zoe Global Limited
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- Hart, Deborah (author)
- King's College London
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- Mangino, Massimo (author)
- King's College London
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- Merino, Jordi (author)
- Massachusetts General Hospital,Broad Institute,Rovira i Virgili University (URV)
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- Linenberg, Inbar (author)
- Zoe Global Limited
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- Wyatt, Patrick (author)
- Zoe Global Limited
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- Ordovas, Jose M. (author)
- Tufts University,Madrid Institute For Advanced Studies (IMDEA) Food Institute
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- Gardner, Christopher D. (author)
- Stanford University
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- Delahanty, Linda M. (author)
- Massachusetts General Hospital
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- Chan, Andrew T. (author)
- Massachusetts General Hospital
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- Segata, Nicola (author)
- University of Trento
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- Franks, Paul W. (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard University,King's College London
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- Spector, Tim D. (author)
- King's College London
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(creator_code:org_t)
- 2020-06-11
- 2020
- English 10 s.
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In: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 26:6, s. 964-973
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Abstract
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- Metabolic responses to food influence risk of cardiometabolic disease, but large-scale high-resolution studies are lacking. We recruited n = 1,002 twins and unrelated healthy adults in the United Kingdom to the PREDICT 1 study and assessed postprandial metabolic responses in a clinical setting and at home. We observed large inter-individual variability (as measured by the population coefficient of variation (s.d./mean, %)) in postprandial responses of blood triglyceride (103%), glucose (68%) and insulin (59%) following identical meals. Person-specific factors, such as gut microbiome, had a greater influence (7.1% of variance) than did meal macronutrients (3.6%) for postprandial lipemia, but not for postprandial glycemia (6.0% and 15.4%, respectively); genetic variants had a modest impact on predictions (9.5% for glucose, 0.8% for triglyceride, 0.2% for C-peptide). Findings were independently validated in a US cohort (n = 100 people). We developed a machine-learning model that predicted both triglyceride (r = 0.47) and glycemic (r = 0.77) responses to food intake. These findings may be informative for developing personalized diet strategies. The ClinicalTrials.gov registration identifier is NCT03479866.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Berry, Sarah E.
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Valdes, Ana M.
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Drew, David A.
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Asnicar, Frances ...
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Mazidi, Mohsen
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Wolf, Jonathan
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show more...
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Capdevila, Joan
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Hadjigeorgiou, G ...
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Davies, Richard
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Al Khatib, Haya
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Bonnett, Christo ...
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Ganesh, Sajaysur ...
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Bakker, Elco
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Hart, Deborah
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Mangino, Massimo
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Merino, Jordi
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Linenberg, Inbar
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Wyatt, Patrick
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Ordovas, Jose M.
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Gardner, Christo ...
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Delahanty, Linda ...
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Chan, Andrew T.
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Segata, Nicola
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Franks, Paul W.
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Spector, Tim D.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
- Articles in the publication
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Nature Medicine
- By the university
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Lund University