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Sökning: onr:"swepub:oai:lup.lub.lu.se:9fc33cc7-2dbf-4d4b-a023-3c521d63aa12" > Occupation and occu...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003894naa a2200469 4500
001oai:lup.lub.lu.se:9fc33cc7-2dbf-4d4b-a023-3c521d63aa12
003SwePub
008160401s2010 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/17530342 URI
0247 a https://doi.org/10.1136/oem.2009.0521752 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Villeneuve, Sara4 aut
2451 0a Occupation and occupational exposure to endocrine disrupting chemicals in male breast cancer: a case-control study in Europe
264 c 2010-08-25
264 1b BMJ,c 2010
520 a Objectives Male breast cancer is a rare disease of largely unknown aetiology. In addition to genetic and hormone-related risk factors, a large number of environmental chemicals are suspected of playing a role in breast cancer. The identification of occupations or occupational exposures associated with an increased incidence of breast cancer in men may help to identify mammary carcinogens in the environment. Methods Occupational risk factors for male breast cancer were investigated in a multi-centre case-control study conducted in eight European countries which included 104 cases and 1901 controls. Lifetime work history was obtained during in-person interviews. Occupational exposures to endocrine disrupting chemicals (alkylphenolic compounds, phthalates, polychlorinated biphenyls and dioxins) were assessed on a case-by-case basis using expert judgement. Results Male breast cancer incidence was particularly increased in motor vehicle mechanics (OR 2.1, 95% CI 1.0 to 4.4) with a dose-effect relationship with duration of employment. It was also increased in paper makers and painters, forestry and logging workers, health and social workers, and furniture manufacture workers. The OR for exposure to alkylphenolic compounds above the median was 3.8 (95% CI 1.5 to 9.5). This association persisted after adjustment for occupational exposures to other environmental oestrogens. Conclusion These findings suggest that some environmental chemicals are possible mammary carcinogens. Petrol, organic petroleum solvents or polycyclic aromatic hydrocarbons are suspect because of the consistent elevated risk of male breast cancer observed in motor vehicle mechanics. Endocrine disruptors such as alkylphenolic compounds may play a role in breast cancer.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng
7001 a Cyr, Diane4 aut
7001 a Lynge, Elsebeth4 aut
7001 a Orsi, Laurent4 aut
7001 a Sabroe, Svend4 aut
7001 a Merletti, Franco4 aut
7001 a Gorini, Giuseppe4 aut
7001 a Morales-Suarez-Varela, Maria4 aut
7001 a Ahrens, Wolfgang4 aut
7001 a Baumgardt-Elms, Cornelia4 aut
7001 a Kaerlev, Linda4 aut
7001 a Eriksson, Mikaelu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-mer
7001 a Hardell, Lennart4 aut
7001 a Fevotte, Joelle4 aut
7001 a Guenel, Pascal4 aut
7102 a Bröstcancer-genetikb Sektion I4 org
7730 t Occupational and Environmental Medicined : BMJg 67:12, s. 837-844q 67:12<837-844x 1470-7926x 1351-0711
8564 u http://dx.doi.org/10.1136/oem.2009.052175x freey FULLTEXT
8564 u https://europepmc.org/articles/pmc3151527
8564 8u https://lup.lub.lu.se/record/1753034
8564 8u https://doi.org/10.1136/oem.2009.052175

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