Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci.

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Fältnamn	Indikatorer	Metadata
000		08070naa a2201921 4500
001		oai:lup.lub.lu.se:9ff78ce1-5738-4c31-8c05-df340032750d
003		SwePub
008		160401s2014 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/43341542 URI
024	7	a https://doi.org/10.1016/j.ajhg.2013.12.0162 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Tragante, Vinicius4 aut
245	1 0	a Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci.
264	1	b Elsevier BV,c 2014
520		a Blood pressure (BP) is a heritable risk factor for cardiovascular disease. To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP), we genotyped ∼50,000 SNPs in up to 87,736 individuals of European ancestry and combined these in a meta-analysis. We replicated findings in an independent set of 68,368 individuals of European ancestry. Our analyses identified 11 previously undescribed associations in independent loci containing 31 genes including PDE1A, HLA-DQB1, CDK6, PRKAG2, VCL, H19, NUCB2, RELA, HOXC@ complex, FBN1, and NFAT5 at the Bonferroni-corrected array-wide significance threshold (p < 6 × 10(-7)) and confirmed 27 previously reported associations. Bioinformatic analysis of the 11 loci provided support for a putative role in hypertension of several genes, such as CDK6 and NUCB2. Analysis of potential pharmacological targets in databases of small molecules showed that ten of the genes are predicted to be a target for small molecules. In summary, we identified previously unknown loci associated with BP. Our findings extend our understanding of genes involved in BP regulation, which may provide new targets for therapeutic intervention or drug response stratification.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700	1	a Barnes, Michael R4 aut
700	1	a Ganesh, Santhi K4 aut
700	1	a Lanktree, Matthew B4 aut
700	1	a Guo, Wei4 aut
700	1	a Franceschini, Nora4 aut
700	1	a Smith, Erin N4 aut
700	1	a Johnson, Toby4 aut
700	1	a Holmes, Michael V4 aut
700	1	a Padmanabhan, Sandosh4 aut
700	1	a Karczewski, Konrad J4 aut
700	1	a Almoguera, Berta4 aut
700	1	a Barnard, John4 aut
700	1	a Baumert, Jens4 aut
700	1	a Chang, Yen-Pei Christy4 aut
700	1	a Elbers, Clara C4 aut
700	1	a Farrall, Martin4 aut
700	1	a Fischer, Mary E4 aut
700	1	a Gaunt, Tom R4 aut
700	1	a Gho, Johannes M I H4 aut
700	1	a Gieger, Christian4 aut
700	1	a Goel, Anuj4 aut
700	1	a Gong, Yan4 aut
700	1	a Isaacs, Aaron4 aut
700	1	a Kleber, Marcus E4 aut
700	1	a Leach, Irene Mateo4 aut
700	1	a McDonough, Caitrin W4 aut
700	1	a Meijs, Matthijs F L4 aut
700	1	a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome
700	1	a Nelson, Christopher P4 aut
700	1	a Nolte, Ilja M4 aut
700	1	a Pankratz, Nathan4 aut
700	1	a Price, Tom S4 aut
700	1	a Shaffer, Jonathan4 aut
700	1	a Shah, Sonia4 aut
700	1	a Tomaszewski, Maciej4 aut
700	1	a van der Most, Peter J4 aut
700	1	a Van Iperen, Erik P A4 aut
700	1	a Vonk, Judith M4 aut
700	1	a Witkowska, Kate4 aut
700	1	a Wong, Caroline O L4 aut
700	1	a Zhang, Li4 aut
700	1	a Beitelshees, Amber L4 aut
700	1	a Berenson, Gerald S4 aut
700	1	a Bhatt, Deepak L4 aut
700	1	a Brown, Morris4 aut
700	1	a Burt, Amber4 aut
700	1	a Cooper-Dehoff, Rhonda M4 aut
700	1	a Connell, John M4 aut
700	1	a Cruickshanks, Karen J4 aut
700	1	a Curtis, Sean P4 aut
700	1	a Davey-Smith, George4 aut
700	1	a Delles, Christian4 aut
700	1	a Gansevoort, Ron T4 aut
700	1	a Guo, Xiuqing4 aut
700	1	a Haiqing, Shen4 aut
700	1	a Hastie, Claire E4 aut
700	1	a Hofker, Marten H4 aut
700	1	a Hovingh, G Kees4 aut
700	1	a Kim, Daniel S4 aut
700	1	a Kirkland, Susan A4 aut
700	1	a Klein, Barbara E4 aut
700	1	a Klein, Ronald4 aut
700	1	a Li, Yun R4 aut
700	1	a Maiwald, Steffi4 aut
700	1	a Newton-Cheh, Christopher4 aut
700	1	a O'Brien, Eoin T4 aut
700	1	a Onland-Moret, N Charlotte4 aut
700	1	a Palmas, Walter4 aut
700	1	a Parsa, Afshin4 aut
700	1	a Penninx, Brenda W4 aut
700	1	a Pettinger, Mary4 aut
700	1	a Vasan, Ramachandran S4 aut
700	1	a Ranchalis, Jane E4 aut
700	1	a M Ridker, Paul4 aut
700	1	a Rose, Lynda M4 aut
700	1	a Sever, Peter4 aut
700	1	a Shimbo, Daichi4 aut
700	1	a Steele, Laura4 aut
700	1	a Stolk, Ronald P4 aut
700	1	a Thorand, Barbara4 aut
700	1	a Trip, Mieke D4 aut
700	1	a van Duijn, Cornelia M4 aut
700	1	a Verschuren, W Monique4 aut
700	1	a Wijmenga, Cisca4 aut
700	1	a Wyatt, Sharon4 aut
700	1	a Young, J Hunter4 aut
700	1	a Zwinderman, Aeilko H4 aut
700	1	a Bezzina, Connie R4 aut
700	1	a Boerwinkle, Eric4 aut
700	1	a Casas, Juan P4 aut
700	1	a Caulfield, Mark J4 aut
700	1	a Chakravarti, Aravinda4 aut
700	1	a Chasman, Daniel I4 aut
700	1	a Davidson, Karina W4 aut
700	1	a Doevendans, Pieter A4 aut
700	1	a Dominiczak, Anna F4 aut
700	1	a Fitzgerald, Garret A4 aut
700	1	a Gums, John G4 aut
700	1	a Fornage, Myriam4 aut
700	1	a Hakonarson, Hakon4 aut
700	1	a Halder, Indrani4 aut
700	1	a Hillege, Hans L4 aut
700	1	a Illig, Thomas4 aut
700	1	a Jarvik, Gail P4 aut
700	1	a Johnson, Julie A4 aut
700	1	a Kastelein, John J P4 aut
700	1	a Koenig, Wolfgang4 aut
700	1	a Kumari, Meena4 aut
700	1	a März, Winfried4 aut
700	1	a Murray, Sarah S4 aut
700	1	a O'Connell, Jeffery R4 aut
700	1	a Oldehinkel, Albertine J4 aut
700	1	a Pankow, James S4 aut
700	1	a Rader, Daniel J4 aut
700	1	a Redline, Susan4 aut
700	1	a Reilly, Muredach P4 aut
700	1	a Schadt, Eric E4 aut
700	1	a Kottke-Marchant, Kandice4 aut
700	1	a Snieder, Harold4 aut
700	1	a Snyder, Michael4 aut
700	1	a Stanton, Alice V4 aut
700	1	a Tobin, Martin D4 aut
700	1	a Uitterlinden, André G4 aut
700	1	a van der Harst, Pim4 aut
700	1	a van der Schouw, Yvonne T4 aut
700	1	a Samani, Nilesh J4 aut
700	1	a Watkins, Hugh4 aut
700	1	a Johnson, Andrew D4 aut
700	1	a Reiner, Alex P4 aut
700	1	a Zhu, Xiaofeng4 aut
700	1	a de Bakker, Paul I W4 aut
700	1	a Levy, Daniel4 aut
700	1	a Asselbergs, Folkert W4 aut
700	1	a Munroe, Patricia B4 aut
700	1	a Keating, Brendan J4 aut
710	2	a Kardiovaskulär forskning - hypertonib Forskargrupper vid Lunds universitet4 org
773	0	t American Journal of Human Geneticsd : Elsevier BVg 94:3, s. 349-360q 94:3<349-360x 0002-9297
856	4	u http://www.ncbi.nlm.nih.gov/pubmed/24560520?dopt=Abstracty FULLTEXT
856	4	u http://dx.doi.org/10.1016/j.ajhg.2013.12.016y FULLTEXT
856	4	u http://www.cell.com/article/S0002929713006137/pdf
856	4 8	u https://lup.lub.lu.se/record/4334154
856	4 8	u https://doi.org/10.1016/j.ajhg.2013.12.016

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Av författaren/redakt...: Tragante, Vinici ...; Barnes, Michael ...; Ganesh, Santhi K; Lanktree, Matthe ...; Guo, Wei; Franceschini, No ...; visa fler...; Smith, Erin N; Johnson, Toby; Holmes, Michael ...; Padmanabhan, San ...; Karczewski, Konr ...; Almoguera, Berta; Barnard, John; Baumert, Jens; Chang, Yen-Pei C ...; Elbers, Clara C; Farrall, Martin; Fischer, Mary E; Gaunt, Tom R; Gho, Johannes M ...; Gieger, Christia ...; Goel, Anuj; Gong, Yan; Isaacs, Aaron; Kleber, Marcus E; Leach, Irene Mat ...; McDonough, Caitr ...; Meijs, Matthijs ...; Melander, Olle; Nelson, Christop ...; Nolte, Ilja M; Pankratz, Nathan; Price, Tom S; Shaffer, Jonatha ...; Shah, Sonia; Tomaszewski, Mac ...; van der Most, Pe ...; Van Iperen, Erik ...; Vonk, Judith M; Witkowska, Kate; Wong, Caroline O ...; Zhang, Li; Beitelshees, Amb ...; Berenson, Gerald ...; Bhatt, Deepak L; Brown, Morris; Burt, Amber; Cooper-Dehoff, R ...; Connell, John M; Cruickshanks, Ka ...; Curtis, Sean P; Davey-Smith, Geo ...; Delles, Christia ...; Gansevoort, Ron ...; Guo, Xiuqing; Haiqing, Shen; Hastie, Claire E; Hofker, Marten H; Hovingh, G Kees; Kim, Daniel S; Kirkland, Susan ...; Klein, Barbara E; Klein, Ronald; Li, Yun R; Maiwald, Steffi; Newton-Cheh, Chr ...; O'Brien, Eoin T; Onland-Moret, N ...; Palmas, Walter; Parsa, Afshin; Penninx, Brenda ...; Pettinger, Mary; Vasan, Ramachand ...; Ranchalis, Jane ...; M Ridker, Paul; Rose, Lynda M; Sever, Peter; Shimbo, Daichi; Steele, Laura; Stolk, Ronald P; Thorand, Barbara; Trip, Mieke D; van Duijn, Corne ...; Verschuren, W Mo ...; Wijmenga, Cisca; Wyatt, Sharon; Young, J Hunter; Zwinderman, Aeil ...; Bezzina, Connie ...; Boerwinkle, Eric; Casas, Juan P; Caulfield, Mark ...; Chakravarti, Ara ...; Chasman, Daniel ...; Davidson, Karina ...; Doevendans, Piet ...; Dominiczak, Anna ...; Fitzgerald, Garr ...; Gums, John G; Fornage, Myriam; Hakonarson, Hako ...; Halder, Indrani; Hillege, Hans L; Illig, Thomas; Jarvik, Gail P; Johnson, Julie A; Kastelein, John ...; Koenig, Wolfgang; Kumari, Meena; März, Winfried; Murray, Sarah S; O'Connell, Jeffe ...; Oldehinkel, Albe ...; Pankow, James S; Rader, Daniel J; Redline, Susan; Reilly, Muredach ...; Schadt, Eric E; Kottke-Marchant, ...; Snieder, Harold; Snyder, Michael; Stanton, Alice V; Tobin, Martin D; Uitterlinden, An ...; van der Harst, P ...; van der Schouw, ...; Samani, Nilesh J; Watkins, Hugh; Johnson, Andrew ...; Reiner, Alex P; Zhu, Xiaofeng; de Bakker, Paul ...; Levy, Daniel; Asselbergs, Folk ...; Munroe, Patricia ...; Keating, Brendan ...; visa färre...

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