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Sökning: onr:"swepub:oai:lup.lub.lu.se:a33977ad-dbcc-4659-9add-2f514d92fd2f" > Inhibition of fatty...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
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003SwePub
008210222s2021 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:146080721
009oai:DiVA.org:uu-440476
0247 a https://lup.lub.lu.se/record/a33977ad-dbcc-4659-9add-2f514d92fd2f2 URI
0247 a https://doi.org/10.1016/j.isci.2021.1021282 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1460807212 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4404762 URI
040 a (SwePub)lud (SwePub)kid (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Ruiz-Pérez, María Victoriau Karolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, Biomed B7, S-17165 Stockholm, Sweden.4 aut
2451 0a Inhibition of fatty acid synthesis induces differentiation and reduces tumor burden in childhood neuroblastoma
264 1b Elsevier BV,c 2021
520 a Many metabolic pathways, including lipid metabolism, are rewired in tumors to support energy and biomass production and to allow adaptation to stressful environments. Neuroblastoma is the second deadliest solid tumor in children. Genetic aberrations, as the amplification of the MYCN-oncogene, correlate strongly with disease progression. Yet, there are only a few molecular targets successfully exploited in the clinic. Here we show that inhibition of fatty acid synthesis led to increased neural differentiation and reduced tumor burden in neuroblastoma xenograft experiments independently of MYCN-status. This was accompanied by reduced levels of the MYCN or c-MYC oncoproteins and activation of ERK signaling. Importantly, the expression levels of genes involved in de novo fatty acid synthesis showed prognostic value for neuroblastoma patients. Our findings demonstrate that inhibition of de novo fatty acid synthesis is a promising pharmacological intervention strategy for the treatment of neuroblastoma independently of MYCN-status.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a biological sciences
653 a cancer
653 a cell biology
653 a molecular biology
7001 a Sainero-Alcolado, Lourdesu Karolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, Biomed B7, S-17165 Stockholm, Sweden.4 aut
7001 a Oliynyk, Gannau Karolinska Institute,Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, Biomed B7, S-17165 Stockholm, Sweden.4 aut
7001 a Matuschek, Isabellu Karolinska Institute,Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, Biomed B7, S-17165 Stockholm, Sweden.4 aut
7001 a Balboni, Nicolau Karolinska Institute,Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, Biomed B7, S-17165 Stockholm, Sweden.4 aut
7001 a Ubhayasekera, Kumariu Uppsala universitet,Uppsala University,Analytisk kemi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)kumub884
7001 a Snaebjornsson, Marteinn Thoru German Cancer Research Centre,German Canc Res Ctr, Tumor Metab & Microenvironm, D-69120 Heidelberg, Germany.4 aut
7001 a Makowski, Kamilu University of Barcelona,Univ Barcelona, Fac Chem, Dept Inorgan & Organ Chem, Sect Organ Chem, Barcelona 08028, Spain.4 aut
7001 a Aaltonen, Kristinau Lund University,Lunds universitet,Molekylär barnonkologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Molecular Pediatric Oncology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Lund Univ, Translat Canc Res, S-22381 Lund, Sweden.4 aut0 (Swepub:lu)cob-ked
7001 a Bexell, Danielu Lund University,Lunds universitet,Molekylär barnonkologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Molecular Pediatric Oncology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Lund Univ, Translat Canc Res, S-22381 Lund, Sweden.4 aut0 (Swepub:lu)stem-dbe
7001 a Serra, Dolorsu Carlos III Health Institute,University of Barcelona,CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN),Univ Barcelona, Dept Biochem & Physiol, Sch Pharm, Inst Biomed,Univ Barcelona IBUB, Barcelona 08028, Spain.;Inst Hlth Carlos III, BER Physiopathol Obes & Nutr CIBEROBN, Madrid 28029, Spain.4 aut
7001 a Nilsson, Rolandu Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Dept Med, Cardiovasc Med Unit, S-17176 Stockholm, Sweden.;Karolinska Univ Hosp, Div Cardiovasc Med, S-17176 Stockholm, Sweden.;Karolinska Inst, Ctr Mol Med, S-17176 Stockholm, Sweden.4 aut
7001 a Bergquist, Jonasu Uppsala universitet,Uppsala University,Analytisk kemi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)jbe25356
7001 a Schulze, Almutu German Cancer Research Centre,German Canc Res Ctr, Tumor Metab & Microenvironm, D-69120 Heidelberg, Germany.4 aut
7001 a Arsenian-Henriksson, Marieu Karolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, Biomed B7, S-17165 Stockholm, Sweden.4 aut
7102 a Karolinska Institutetb Karolinska Institute4 org
7730 t iScienced : Elsevier BVg 24:2q 24:2x 2589-0042
8564 u http://dx.doi.org/10.1016/j.isci.2021.102128x freey FULLTEXT
8564 u http://www.cell.com/article/S2589004221000961/pdf
8564 u https://doi.org/10.1016/j.isci.2021.102128y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1545351/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://lup.lub.lu.se/record/a33977ad-dbcc-4659-9add-2f514d92fd2f
8564 8u https://doi.org/10.1016/j.isci.2021.102128
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:146080721
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-440476

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