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Cystatin C, a human proteinase inhibitor, blocks replication of herpes simplex virus
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- Björck, Lars (author)
- Lund University,Lunds universitet,Medicinska fakulteten,Faculty of Medicine
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- Grubb, Anders (author)
- Skåne University Hospital
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- Kjellén, Lars (author)
- Lund University
- (creator_code:org_t)
- 1990
- 1990
- English.
- In: Journal of Virology. - 0022-538X. ; 64:2, s. 941-943
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Cystatin C is a human cysteine proteinase inhibitor present in extracellular fluids. Cystatin C and a tripeptide derivative (Z-LVG-CHN2) that mimics its proteinase-binding center, were tested for possible antiviral activity against herpes simplex virus type 1 (HSV) and poliovirus type 1. Both recombinant cystatin C and Z-LVG-CHN2 displayed strong inhibitory effects on HSV replication, whereas no significant effect on poliovirus replication was seen. The molar concentration of cystatin C that gave total inhibition of HSV replication was lower than that of either Z-LVG-CHN2 or of acyclovir, the drug currently most used against HSV infections. These results suggest that cysteine proteinase inhibitors might play a physiological role as inhibitors of viral replication and that such proteinase inhibitors, or peptide derivatives that mimic their proteinase-binding centers, might be used as antiviral agents.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Keyword
- Amino Acid Sequence
- Animals
- Antiviral Agents/pharmacology
- Cell Line
- Cerebrospinal Fluid Proteins/pharmacology
- Cystatin C
- Cystatins/pharmacology
- Kinetics
- Molecular Sequence Data
- Oligopeptides/pharmacology
- Simplexvirus/drug effects
- Virus Replication/drug effects
Publication and Content Type
- art (subject category)
- ref (subject category)
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