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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04637naa a2200385 4500 | |
| 001 | oai:lup.lub.lu.se:aba6058c-293f-42a0-ab2f-35d8f163e22a | |
| 003 | SwePub | |
| 008 | 160401s2015 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/49086972 URI |
| 024 | 7 | a https://doi.org/10.1038/jcbfm.2014.2172 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Ahnstedt, Hildau Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-hat |
| 245 | 1 0 | a U0126 attenuates cerebral vasoconstriction and improves long-term neurologic outcome after stroke in female rats. |
| 264 | c 2015-03-01 | |
| 264 | 1 | b SAGE Publications,c 2015 |
| 520 | a Sex differences are well known in cerebral ischemia and may impact the effect of stroke treatments. In male rats, the MEK1/2 inhibitor U0126 reduces ischemia-induced endothelin type B (ETB) receptor upregulation, infarct size and improves acute neurologic function after experimental stroke. However, responses to this treatment in females and long-term effects on outcome are not known. Initial experiments used in vitro organ culture of cerebral arteries, confirming ERK1/2 activation and increased ETB receptor-mediated vasoconstriction in female cerebral arteries. Transient middle cerebral artery occlusion (tMCAO, 120 minutes) was induced in female Wistar rats, with U0126 (30 mg/kg intraperitoneally) or vehicle administered at 0 and 24 hours of reperfusion, or with no treatment. Infarct volumes were determined and neurologic function was assessed by 6-point and 28-point neuroscores. ETB receptor-mediated contraction was studied with myograph and protein expression with immunohistochemistry. In vitro organ culture and tMCAO resulted in vascular ETB receptor upregulation and activation of ERK1/2 that was prevented by U0126. Although no effect on infarct size, U0126 improved the long-term neurologic function after experimental stroke in female rats. In conclusion, early prevention of the ERK1/2 activation and ETB receptor-mediated vasoconstriction in the cerebral vasculature after ischemic stroke in female rats improves the long-term neurologic outcome.Journal of Cerebral Blood Flow & Metabolism advance online publication, 10 December 2014; doi:10.1038/jcbfm.2014.217. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
| 700 | 1 | a Mostajeran, Maryamu Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-mmj |
| 700 | 1 | a Blixt, Franku Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-fbl |
| 700 | 1 | a Warfvinge, Karinu Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)oft-kwa |
| 700 | 1 | a Ansar, Saemau Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-sbe |
| 700 | 1 | a Krause, Diana N4 aut |
| 700 | 1 | a Edvinsson, Larsu Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-led |
| 710 | 2 | a Medicin, Lundb Sektion II4 org |
| 773 | 0 | t Journal of Cerebral Blood Flow and Metabolismd : SAGE Publicationsg 35:3, s. 454-460q 35:3<454-460x 1559-7016x 0271-678X |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/25492115?dopt=Abstracty FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1038/jcbfm.2014.217y FULLTEXT |
| 856 | 4 | u https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2014.217 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/4908697 |
| 856 | 4 8 | u https://doi.org/10.1038/jcbfm.2014.217 |
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