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Search: onr:"swepub:oai:lup.lub.lu.se:b63f6124-2941-466e-aeda-6af9c2168cc5" > Mast Cell Activatio...

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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004478naa a2200469 4500
001oai:lup.lub.lu.se:b63f6124-2941-466e-aeda-6af9c2168cc5
003SwePub
008210820s2021 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:147551728
0247 a https://lup.lub.lu.se/record/b63f6124-2941-466e-aeda-6af9c2168cc52 URI
0247 a https://doi.org/10.1161/JAHA.121.0210022 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1475517282 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Kohno, Ritsukou University of Minnesota4 aut
2451 0a Mast Cell Activation Disorder and Postural Orthostatic Tachycardia Syndrome : A Clinical Association
264 1c 2021
520 a Background Recently there has been increased interest in a possible association between mast cell activation (MCA) disorder and postural orthostatic tachycardia syndrome (POTS). This study examined the frequency with which symptoms and laboratory findings suggesting MCA disorder occurred in patients diagnosed with POTS. Methods and Results Data were obtained from patients in whom symptoms and orthostatic testing were consistent with a POTS diagnosis. Individuals with <4 months symptom duration, evident ongoing inflammatory disease, suspected volume depletion, or declined consent were excluded. All patients had typical POTS symptoms; some, however, had additional nonorthostatic complaints not usually associated with POTS. The latter patients underwent additional testing for known MCA biochemical mediators including prostaglandins, histamine, methylhistamine, and plasma tryptase. The study comprised 69 patients who met POTS diagnostic criteria. In 44 patients (44/69, 64%) additional nonorthostatic symptoms included migraine, allergic complaints, skin rash, or gastrointestinal symptoms. Of these 44 patients, 29 (66%) exhibited at least 1 laboratory abnormality suggesting MCA disorder, and 11/29 patients had 2 or more such abnormalities. Elevated prostaglandins (n=16) or plasma histamine markers (n=23) were the most frequent findings. Thus, 42% (29/69) of patients initially diagnosed with POTS exhibited both additional symptoms and at least 1 elevated biochemical marker suggesting MCA disorder. Conclusions Laboratory findings suggesting MCA disorder were relatively common in patients diagnosed with POTS and who present with additional nonorthostatic gastrointestinal, cutaneous, and allergic symptoms. While solitary abnormal laboratory findings are not definitive, they favor MCA disorder being considered in such cases.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a mast cell
653 a postural orthostatic tachycardia syndrome
653 a biochemical mediators
653 a histamine
653 a prostaglandins
7001 a Cannom, David Su PIH Health Good Samaritan Hospital,University of Southern California4 aut
7001 a Olshansky, Brianu University of Iowa4 aut
7001 a Xi, Shijun Cindyu University of Southern California4 aut
7001 a Krishnappa, Darshanu University of Minnesota4 aut
7001 a Adkisson, Wayne Ou University of Minnesota4 aut
7001 a Norby, Faye Lu Cedars-Sinai Medical Center4 aut
7001 a Fedorowski, Arturu Karolinska Institutet,Karolinska Institute,Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Cardiovascular Research - Hypertension,Lund University Research Groups,Karolinska University Hospital4 aut0 (Swepub:lu)med-afr
7001 a Benditt, David Gu University of Minnesota4 aut
7102 a University of Minnesotab PIH Health Good Samaritan Hospital4 org
7730 t Journal of the American Heart Associationg 10:17q 10:17x 2047-9980
8564 u http://dx.doi.org/10.1161/JAHA.121.021002x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/b63f6124-2941-466e-aeda-6af9c2168cc5
8564 8u https://doi.org/10.1161/JAHA.121.021002
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:147551728

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