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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04600naa a2200337 4500 | |
| 001 | oai:lup.lub.lu.se:bc40486f-38fc-4586-85a5-cbfc5159a16b | |
| 003 | SwePub | |
| 008 | 191108s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/bc40486f-38fc-4586-85a5-cbfc5159a16b2 URI |
| 024 | 7 | a https://doi.org/10.1007/s11060-019-03321-w2 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Huang, Wuqingu Lund University,Lunds universitet,Allmänmedicin, kardiovaskulär epidemiologi och levnadsvanor,Forskargrupper vid Lunds universitet,Allmänmedicin och klinisk epidemiologi,Family Medicine, Cardiovascular Epidemiology and Lifestyle,Lund University Research Groups,Family Medicine and Clinical Epidemiology,Center for Primary Health Care Research4 aut0 (Swepub:lu)wu2467hu |
| 245 | 1 0 | a Mortality patterns in long-term survivors of childhood or adolescent central nervous system tumour in Sweden |
| 264 | c 2019-11-01 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2019 |
| 520 | a PURPOSE: A growing number of young patients with central nervous system (CNS) tumour survived for more than five years. However, these long-term survivors might be at risk of multiple late effects thus leading to a higher risk of late mortality. We aimed to explore the risk of late mortality and the pattern of mortality among long-term survivors of childhood or adolescent CNS tumour.METHODS: We identified 5-year survivors with childhood or adolescent CNS tumour before age 20 years through the Swedish Cancer Registry. Five controls were randomly matched for each patient to generate the reference group. We retrieved information about death via Cause of Death Register. We calculated the absolute excess risk (AER) of death and the hazard ratio (HR) of death using Cox proportional hazard model.RESULTS: Long-term survivors with CNS tumour suffered a significant higher risk of overall mortality (HR 6.56, 95% CI 5.71-7.53; AER 5.89, 95% CI 5.03-6.87). The mortality rate declined with the increasing survival time, but it was still higher even after 30 years of follow-up. Malignant neoplasms contributed mostly to late mortality with an AER of 3.75 (95% CI 2.95-4.75). Female survivors, survivors diagnosed at a younger age and survivors with medulloblastoma were particularly strongly associated with a higher risk of death.CONCLUSIONS: Long-term survivors of childhood and adolescent CNS tumours are at a higher risk of late mortality, and the risk of death is affected by gender, age at diagnosis and types of CNS tumour. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
| 700 | 1 | a Sundquist, Janu Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Shimane University,Icahn School of Medicine at Mount Sinai,Center for Primary Health Care Research4 aut0 (Swepub:lu)med-jsu |
| 700 | 1 | a Sundquist, Kristinau Lund University,Lunds universitet,Allmänmedicin, kardiovaskulär epidemiologi och levnadsvanor,Forskargrupper vid Lunds universitet,Allmänmedicin och klinisk epidemiologi,Family Medicine, Cardiovascular Epidemiology and Lifestyle,Lund University Research Groups,Family Medicine and Clinical Epidemiology,Center for Primary Health Care Research,Icahn School of Medicine at Mount Sinai,Shimane University4 aut0 (Swepub:lu)med-ksq |
| 700 | 1 | a Ji, Jianguangu Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Center for Primary Health Care Research4 aut0 (Swepub:lu)med-jji |
| 710 | 2 | a Allmänmedicin, kardiovaskulär epidemiologi och levnadsvanorb Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Journal of Neuro-Oncologyd : Springer Science and Business Media LLCg 145:3, s. 541-549q 145:3<541-549x 1573-7373x 0167-594X |
| 856 | 4 | u http://dx.doi.org/10.1007/s11060-019-03321-wx freey FULLTEXT |
| 856 | 4 | u https://link.springer.com/content/pdf/10.1007/s11060-019-03321-w.pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/bc40486f-38fc-4586-85a5-cbfc5159a16b |
| 856 | 4 8 | u https://doi.org/10.1007/s11060-019-03321-w |
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