Search: onr:"swepub:oai:lup.lub.lu.se:bfdf686f-3b20-4dfa-a4d8-9db4536f7f0f" >
Nuclear stabilizati...
Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway
-
- Hannan, Katherine M. (author)
- Peter MacCallum Cancer Centre,University of Melbourne
-
- Soo, Priscilla (author)
- Australian National University
-
- Wong, Mei S. (author)
- Peter MacCallum Cancer Centre,University of Melbourne
-
show more...
-
- Lee, Justine K. (author)
- University of Newcastle upon Tyne
-
- Hein, Nadine (author)
- Australian National University
-
- Poh, Perlita (author)
- Australian National University
-
- Wysoke, Kira D. (author)
- Australian National University
-
Williams, Tobias D. (author)
-
- Montellese, Christian (author)
- ETH Zürich
-
- Smith, Lorey K. (author)
- Peter MacCallum Cancer Centre
-
Al-Obaidi, Sheren J. (author)
-
Núñez-Villacís, Lorena (author)
-
Pavy, Megan (author)
-
- He, Jin Shu (author)
- Australian National University
-
- Parsons, Kate M. (author)
- Australian National University
-
Loring, Karagh E. (author)
-
Morrison, Tess (author)
-
- Diesch, Jeannine (author)
- Peter MacCallum Cancer Centre
-
Burgio, Gaetan (author)
-
Ferreira, Rita (author)
-
Feng, Zhi Ping (author)
-
- Gould, Cathryn M. (author)
- Peter MacCallum Cancer Centre
-
- Madhamshettiwar, Piyush B. (author)
- Peter MacCallum Cancer Centre
-
- Flygare, Johan (author)
- Lund University,Lunds universitet,Stamceller till röda blodkroppar,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Stem Cells to Red Blood Cells,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
-
- Gonda, Thomas J. (author)
- University of Queensland
-
- Simpson, Kaylene J. (author)
- University of Melbourne,Peter MacCallum Cancer Centre
-
- Kutay, Ulrike (author)
- ETH Zürich
-
- Pearson, Richard B. (author)
- University of Melbourne,Monash University,Peter MacCallum Cancer Centre
-
- Engel, Christoph (author)
- University of Regensburg
-
- Watkins, Nicholas J. (author)
- University of Newcastle upon Tyne
-
- Hannan, Ross D. (author)
- Monash University,ETH Zürich,University of Melbourne,University of Queensland,Peter MacCallum Cancer Centre
-
- George, Amee J. (author)
- University of Melbourne,Australian National University
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
-
In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 41:5
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- The nucleolar surveillance pathway monitors nucleolar integrity and responds to nucleolar stress by mediating binding of ribosomal proteins to MDM2, resulting in p53 accumulation. Inappropriate pathway activation is implicated in the pathogenesis of ribosomopathies, while drugs selectively activating the pathway are in trials for cancer. Despite this, the molecular mechanism(s) regulating this process are poorly understood. Using genome-wide loss-of-function screens, we demonstrate the ribosome biogenesis axis as the most potent class of genes whose disruption stabilizes p53. Mechanistically, we identify genes critical for regulation of this pathway, including HEATR3. By selectively disabling the nucleolar surveillance pathway, we demonstrate that it is essential for the ability of all nuclear-acting stresses, including DNA damage, to induce p53 accumulation. Our data support a paradigm whereby the nucleolar surveillance pathway is the central integrator of stresses that regulate nuclear p53 abundance, ensuring that ribosome biogenesis is hardwired to cellular proliferative capacity.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- CP: Molecular biology
- high-content screening
- high-throughput screening
- nucleolar surveillance pathway
- nucleolus
- p53
- ribosomal proteins
- ribosome biogenesis
- stress
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Hannan, Katherin ...
-
Soo, Priscilla
-
Wong, Mei S.
-
Lee, Justine K.
-
Hein, Nadine
-
Poh, Perlita
-
show more...
-
Wysoke, Kira D.
-
Williams, Tobias ...
-
Montellese, Chri ...
-
Smith, Lorey K.
-
Al-Obaidi, Shere ...
-
Núñez-Villacís, ...
-
Pavy, Megan
-
He, Jin Shu
-
Parsons, Kate M.
-
Loring, Karagh E ...
-
Morrison, Tess
-
Diesch, Jeannine
-
Burgio, Gaetan
-
Ferreira, Rita
-
Feng, Zhi Ping
-
Gould, Cathryn M ...
-
Madhamshettiwar, ...
-
Flygare, Johan
-
Gonda, Thomas J.
-
Simpson, Kaylene ...
-
Kutay, Ulrike
-
Pearson, Richard ...
-
Engel, Christoph
-
Watkins, Nichola ...
-
Hannan, Ross D.
-
George, Amee J.
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Biochemistry and ...
- Articles in the publication
-
Cell Reports
- By the university
-
Lund University