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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05054naa a2200361 4500 | |
| 001 | oai:lup.lub.lu.se:c15b7902-a40d-4729-99b5-0e6d12e0dff2 | |
| 003 | SwePub | |
| 008 | 190215s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/c15b7902-a40d-4729-99b5-0e6d12e0dff22 URI |
| 024 | 7 | a https://doi.org/10.1212/WNL.00000000000068752 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Ossenkoppele, Riku Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Amsterdam UMC - Vrije Universiteit Amsterdam4 aut0 (Swepub:lu)ri1513os |
| 245 | 1 0 | a Associations between tau, Aβ, and cortical thickness with cognition in Alzheimer disease |
| 264 | 1 | c 2019 |
| 520 | a OBJECTIVE: To examine the cross-sectional associations between regional tau, β-amyloid (Aβ), and cortical thickness and neuropsychological function across the preclinical and clinical spectrum of Alzheimer disease (AD). METHODS: We included 106 participants from the Swedish Biomarkers for Identifying Neurodegenerative Disorders Early and Reliably (BioFINDER) study, of whom 33 had preclinical AD (Aβ-positive cognitively normal individuals), 25 had prodromal AD (Aβ-positive mild cognitive impairment), and 48 had probable AD dementia. All underwent [18F]flortaucipir (tau) and structural MRI (cortical thickness), and 88 of 106 underwent [18F]flutemetamol (Aβ) PET. Linear regression models adjusted for age, sex, and education were performed to examine associations between 7 regions of interest and 7 neuropsychological tests for all 3 imaging modalities. RESULTS: In preclinical AD, [18F]flortaucipir, but not [18F]flutemetamol or cortical thickness, was associated with decreased global cognition, memory, and processing speed (range standardized β = 0.35-0.52, p < 0.05 uncorrected for multiple comparisons). In the combined prodromal AD and AD dementia group, both increased [18F]flortaucipir uptake and reduced cortical thickness were associated with worse performance on a variety of neuropsychological tests (most regions of interest survived correction for multiple comparisons at p < 0.05), while increased [18F]flutemetamol uptake was specifically associated with lower scores on a delayed recall memory task (p < 0.05 uncorrected for multiple comparisons). The strongest effects for both [18F]flortaucipir and cortical thickness on cognition were found in the lateral and medial parietal cortex and lateral temporal cortex. The effect of [18F]flutemetamol on cognition was generally weaker and less region specific. CONCLUSION: Our findings suggest that tau PET is more sensitive than Aβ PET and measures of cortical thickness for detecting early cognitive changes in preclinical AD. Furthermore, both [18F]flortaucipir PET and cortical thickness show strong cognitive correlates at the clinical stages of AD. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 700 | 1 | a Smith, Rubenu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Regeneration in Movement Disorders,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)mphy-rsm |
| 700 | 1 | a Ohlsson, Tomasu Skåne University Hospital4 aut |
| 700 | 1 | a Strandberg, Olofu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)teor-osn |
| 700 | 1 | a Mattsson, Niklasu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)med-nmn |
| 700 | 1 | a Insel, Philip S.u Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,San Francisco Veterans Administration Medical Center4 aut0 (Swepub:lu)med-ppi |
| 700 | 1 | a Palmqvist, Sebastianu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)med-spa |
| 700 | 1 | a Hansson, Oskaru Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)mphy-ohn |
| 710 | 2 | a Klinisk minnesforskningb Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Neurologyg 92:6, s. 601-612q 92:6<601-612x 1526-632X |
| 856 | 4 | u http://dx.doi.org/10.1212/WNL.0000000000006875x freey FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/c15b7902-a40d-4729-99b5-0e6d12e0dff2 |
| 856 | 4 8 | u https://doi.org/10.1212/WNL.0000000000006875 |
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