onr:"swepub:oai:lup.lub.lu.se:c3b49d92-c523-4dc3-8a45-bc67e97b3284"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02551naa a2200337 4500 | |
| 001 | oai:lup.lub.lu.se:c3b49d92-c523-4dc3-8a45-bc67e97b3284 | |
| 003 | SwePub | |
| 008 | 160404s2001 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/11216262 URI |
| 024 | 7 | a https://doi.org/10.1006/scbi.2001.03932 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Borg, Åkeu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-abo |
| 245 | 1 0 | a Molecular and pathological characterization of inherited breast cancer. |
| 264 | 1 | b Elsevier BV,c 2001 |
| 520 | a The two major breast cancer susceptibility genes, BRCA1 and BRCA2, account for the majority of familial breast–ovarian cancer, but only a modest proportion of breast cancer families without ovarian or male breast cancer. Search for additional breast cancer genes with traditional linkage analysis has so far been unsuccessful, probably due to genetic heterogeneity. Pooling of families of different ethnical, cultural, and geographical origin proved to be a useful approach when identifying BRCA1 and BRCA2, but for genes mutated only in specific populations it is important not to introduce locus heterogeneity by pooling. Genetic heterogeneity can possibly be circumvented by using objective means, such as tumour histopathology or gene expression profiling, for subclassification of families prior to linkage analysis. Also, additional breast cancer genes can be identified by further characterization of the function of BRCA1 and BRCA2 and their interacting proteins. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a breast cancer | |
| 653 | a BRCA1 | |
| 653 | a BRCA2 | |
| 653 | a molecular characterization | |
| 653 | a pathological characterization | |
| 710 | 2 | a Bröstcancer-genetikb Sektion I4 org |
| 773 | 0 | t Seminars in Cancer Biologyd : Elsevier BVg 11:5, s. 375-385q 11:5<375-385x 1096-3650x 1044-579X |
| 856 | 4 | u http://dx.doi.org/10.1006/scbi.2001.0393y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1121626 |
| 856 | 4 8 | u https://doi.org/10.1006/scbi.2001.0393 |
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