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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03877naa a2200421 4500 | |
| 001 | oai:lup.lub.lu.se:d812d616-230f-4894-b2b1-05276c26f50b | |
| 003 | SwePub | |
| 008 | 230815s2023 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:152895465 | |
| 024 | 7 | a https://lup.lub.lu.se/record/d812d616-230f-4894-b2b1-05276c26f50b2 URI |
| 024 | 7 | a https://doi.org/10.3390/nu151125462 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1528954652 URI |
| 040 | a (SwePub)lud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Lampousi, Anna Mariau Karolinska Institutet,Karolinska Institute4 aut |
| 245 | 1 0 | a Antioxidant Nutrients and Risk of Latent Autoimmune Diabetes in Adults and Type 2 Diabetes : A Swedish Case-Control Study and Mendelian Randomization Analysis |
| 264 | 1 | c 2023 |
| 520 | a Antioxidant vitamins C and E are inversely associated with type 1 diabetes (T1D). We investigated if antioxidants are also associated with latent autoimmune diabetes in adults (LADA), with low (LADAlow) and high (LADAhigh) autoantibody levels, type 2 diabetes (T2D), and estimates of beta cell function (HOMA-B) and insulin resistance (HOMA-IR). We used Swedish case-control data with incident cases of LADA (n = 584) and T2D (n = 1989) and matched population-based controls (n = 2276). Odds ratios (OR) and 95% confidence intervals (CI) were calculated per one standard deviation higher beta-carotene, vitamin C, vitamin E, selenium, and zinc intakes. Two-sample Mendelian randomization (MR) analyses assessed causality between genetically predicted circulating antioxidants and LADA, T1D, and T2D, using summary statistics from genome-wide association studies. Among the antioxidants, vitamins C and E were inversely associated with LADAhigh (OR 0.84, CI 0.73, 0.98 and OR 0.80, CI 0.69, 0.94 respectively), but not with LADAlow or T2D. Vitamin E was also associated with higher HOMA-B and lower HOMA-IR. MR analyses estimated an OR of 0.50 (CI 0.20, 1.25) for the effect of vitamin E on T1D, but did not support causal relationships between antioxidants and either LADA or T2D. In conclusion, vitamin E may have a protective effect on autoimmune diabetes, possibly through preserved beta cell function and less insulin resistance. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 653 | a antioxidants | |
| 653 | a autoimmune diabetes | |
| 653 | a LADA | |
| 653 | a type 2 diabetes | |
| 700 | 1 | a Löfvenborg, Josefin E.u Karolinska Institutet,Karolinska Institute4 aut |
| 700 | 1 | a Ahlqvist, Emmau Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups4 aut0 (Swepub:lu)infl-eah |
| 700 | 1 | a Tuomi, Tiinamaijau Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki,Helsinki University Central Hospital,Folkhälsan Research Center4 aut0 (Swepub:lu)ti8736tu |
| 700 | 1 | a Wolk, Alicjau Karolinska Institutet,Karolinska Institute4 aut |
| 700 | 1 | a Carlsson, Sofiau Karolinska Institutet,Karolinska Institute4 aut |
| 710 | 2 | a Karolinska Institutetb Karolinska Institute4 org |
| 773 | 0 | t Nutrientsg 15:11q 15:11x 2072-6643 |
| 856 | 4 | u http://dx.doi.org/10.3390/nu15112546x freey FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/d812d616-230f-4894-b2b1-05276c26f50b |
| 856 | 4 8 | u https://doi.org/10.3390/nu15112546 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:152895465 |
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