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FältnamnIndikatorerMetadata
00009606naa a2200757 4500
001oai:lup.lub.lu.se:d9170eae-50a6-4a33-a13e-9b83f5d34d98
003SwePub
008211209s2022 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-470105
0247 a https://lup.lub.lu.se/record/d9170eae-50a6-4a33-a13e-9b83f5d34d982 URI
0247 a https://doi.org/10.1002/ijc.338172 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4701052 URI
040 a (SwePub)lud (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Byrne, Julianneu Boyne Research Institute,Boyne Res Inst, Drogheda, Ireland.4 aut
2451 0a Impact of era of diagnosis on cause-specific late mortality among 77 423 five-year European survivors of childhood and adolescent cancer : The PanCareSurFup consortium
264 c 2021-10-21
264 1b Wiley,c 2022
520 a Late mortality of European 5-year survivors of childhood or adolescent cancer has dropped over the last 60 years, but excess mortality persists. There is little information concerning secular trends in cause-specific mortality among older European survivors. PanCareSurFup pooled data from 12 cancer registries and clinics in 11 European countries from 77 423 five-year survivors of cancer diagnosed before age 21 between 1940 and 2008 followed for an average age of 21 years and a total of 1.27 million person-years to determine their risk of death using cumulative mortality, standardized mortality ratios (SMR), absolute excess risks (AER), and multivariable proportional hazards regression analyses. At the end of follow-up 9166 survivors (11.8%) had died compared to 927 expected (SMR 9.89, 95% confidence interval [95% CI] 9.69-10.09), AER 6.47 per 1000 person-years, (95% CI 6.32-6.62). At 60 to 68 years of attained age all-cause mortality was still higher than expected (SMR = 2.41, 95% CI 1.90-3.02). Overall cumulative mortality at 25 years from diagnosis dropped from 18.4% (95% CI 16.5-20.4) to 7.3% (95% CI 6.7-8.0) over the observation period. Compared to the diagnosis period 1960 to 1969, the mortality hazard ratio declined for first neoplasms (P for trend <.0001) and for infections (P <.0001); declines in relative mortality from second neoplasms and cardiovascular causes were less pronounced (P =.1105 and P =.0829, respectively). PanCareSurFup is the largest study with the longest follow-up of late mortality among European childhood and adolescent cancer 5-year survivors, and documents significant mortality declines among European survivors into modern eras. However, continuing excess mortality highlights survivors' long-term care needs.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a cardiovascular
653 a causes of death
653 a European
653 a late mortality
653 a second malignant neoplasms
653 a survivors of childhood cancer
653 a cardiovascular
7001 a Schmidtmann, Ireneu Universitätsmedizin Mainz,Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Med Biostat Epidemiol & Informat, Mainz, Germany.4 aut
7001 a Rashid, Humayrau Universitätsmedizin Mainz,Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Med Biostat Epidemiol & Informat, Mainz, Germany.4 aut
7001 a Hagberg, Oskaru Regional Cancer Centre South,Reg Canc Ctr South, Lund, Sweden.4 aut0 (Swepub:lu)mats-oha
7001 a Bagnasco, Francescau Gaslini Children's Hospital,IRCCS Ist Giannina Gaslini, Epidemiol & Biostat Unit, Genoa, Italy.;IRCCS Ist Giannina Gaslini, DOPO Clin, Genoa, Italy.4 aut
7001 a Bardi, Editu Kepler University Hospital Linz,St. Anna Children's Hospital,St Anna Childrens Hosp, Vienna, Austria.;Johannes Kepler Univ Linz, Kepler Univ Hosp GmbH, Dept Pediat & Adolescent Med, Linz, Austria.4 aut
7001 a De Vathaire, Florentu University of Paris-Saclay,Institut Gustave Roussy,Centre for Research in Epidemiology and Population Health (CESP),Ctr Res Epidemiol & Populat Hlth CESP, INSERM, Villejuif, France.;Univ Paris Sud Orsay, Villejuif, France.;Gustave Roussy, Dept Res, Villejuif, France.4 aut
7001 a Essiaf, Samirau SIOPE, Clos Chapelle Aux Champs 30, Brussels, Belgium.4 aut
7001 a Winther, Jeanette Falcku Danish Cancer Society,Aarhus University Hospital,Danish Canc Soc Res Ctr, Copenhagen, Denmark.;Aarhus Univ, Fac Hlth, Dept Clin Med, Aarhus, Denmark.4 aut
7001 a Frey, Evau St. Anna Children's Hospital4 aut
7001 a Gudmundsdottir, Thorgerduru Danish Cancer Society,National University Hospital of Iceland,Danish Canc Soc Res Ctr, Copenhagen, Denmark.;Landspitali Univ Hosp, Childrens Hosp, Reykjavik, Iceland.4 aut
7001 a Haupt, Riccardou Gaslini Children's Hospital,IRCCS Ist Giannina Gaslini, Epidemiol & Biostat Unit, Genoa, Italy.;IRCCS Ist Giannina Gaslini, DOPO Clin, Genoa, Italy.4 aut
7001 a Hawkins, Michael M.u University of Birmingham,Univ Birmingham, Inst Appl Hlth Res, Ctr Childhood Canc Survivor Studies, Birmingham, W Midlands, England.,Univ Turin, Dept Med Sci, Childhood Canc Registry Piedmont, Turin, Italy.;Ctr Canc Prevent CPO Piemonte, Turin, Italy.4 aut
7001 a Jakab, Zsuzsannau Semmelweis University,Semmelweis Univ, Dept Pediat 2, Hungarian Childhood Canc Registry, Budapest, Hungary.4 aut
7001 a Jankovic, Momcilou University of Milano-Bicocca,Univ Milano Bicocca, Fdn MBBM, Pediat Clin, Milan, Italy.;Italian Off Therapy Register OTR, Monza, Italy.4 aut
7001 a Kaatsch, Peteru Johannes-Gutenberg University Mainz,Johannes Gutenberg Univ Mainz, Inst Med Biostat Epidemiol & Informat IMBEI, Div Childhood Canc Epidemiol, German Childhood Canc Registry GCCR, Mainz, Germany.4 aut
7001 a Kremer, Leontien C.M.u Academic Medical Center of University of Amsterdam (AMC),Emma Childrens Hosp, Amsterdam UMC, Dept Pediat Oncol, Amsterdam, Netherlands.4 aut
7001 a Kuehni, Claudia E.u University Children's Hospital Bern,Univ Bern, Inst Social & Prevent Med, Swiss Childhood Canc Registry, Bern, Switzerland.;Univ Bern, Univ Childrens Hosp Bern, Dept Paediat, Paediat Oncol, Bern, Switzerland.4 aut
7001 a Harila-Saari, Arja H.u Uppsala universitet,Uppsala University,Barnonkologisk och neurologisk forskning4 aut0 (Swepub:uu)arjha456
7001 a Levitt, Gillu Great Ormond Street Hospital,Great Ormond St Hosp Children NHS Fdn Trust, Great Ormond St, London, England.4 aut
7001 a Reulen, Raoulu University of Birmingham,Univ Birmingham, Inst Appl Hlth Res, Ctr Childhood Canc Survivor Studies, Birmingham, W Midlands, England.4 aut
7001 a Ronckers, Cécile M.u Princess Maxima Center for Pediatric Oncology/Hematology,Princess Maxima Ctr Paediat Oncol, Utrecht, Netherlands.;Inst Biostat & Registry Res, Brandenburg Med Sch, Neuruppin, Germany.4 aut
7001 a Maule, Milenau University of Turin4 aut
7001 a Skinner, Rodericku University of Newcastle upon Tyne,Royal Victoria Infirmary,Newcastle Univ, Ctr Canc, Translat & Clin Res Inst, Newcastle Upon Tyne, Tyne & Wear, England.;Great North Childrens Hosp, Royal Victoria Infirm, Dept Paediat & Adolescent Haematol & Oncol, Newcastle Upon Tyne, Tyne & Wear, England.4 aut
7001 a Steliarova-Foucher, Evau International Agency for Research on Cancer, World Health Organization,Int Agcy Res Canc, Sect Canc Surveillance, Lyon, France.4 aut
7001 a Terenziani, Monicau Istituto Nazionale dei Tumori,Fdn IRCCS Ist Nazl Tumori, Pediat Oncol Unit, Milan, Italy.4 aut
7001 a Zaletel, Lorna Zadravecu Institute of Oncology, Ljubljana,Inst Oncol, Div Radiotherapy, Ljubljana, Slovenia.4 aut
7001 a Hjorth, Larsu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital,Lund Univ, Skane Univ Hosp, Dept Clin Sci Lund, Lund, Sweden.4 aut0 (Swepub:lu)pedi-lhj
7001 a Garwicz, Stanislawu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital,Lund Univ, Skane Univ Hosp, Dept Clin Sci Lund, Lund, Sweden.4 aut0 (Swepub:lu)st6750ga
7001 a Grabow, Desireeu Johannes-Gutenberg University Mainz4 aut
7102 a Boyne Research Instituteb Boyne Res Inst, Drogheda, Ireland.4 org
7730 t International Journal of Cancerd : Wileyg 150:3, s. 406-419q 150:3<406-419x 0020-7136x 1097-0215
8564 u http://dx.doi.org/10.1002/ijc.33817y FULLTEXT
8564 8u https://lup.lub.lu.se/record/d9170eae-50a6-4a33-a13e-9b83f5d34d98
8564 8u https://doi.org/10.1002/ijc.33817
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-470105

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