onr:"swepub:oai:lup.lub.lu.se:d951b6b1-d703-41a3-bb0a-6714d5669408"
Sökning: onr:"swepub:oai:lup.lub.lu.se:d951b6b1-d703-41a3-bb0a-6714d5669408" > Physiological and g...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04441naa a2200505 4500 | |
| 001 | oai:lup.lub.lu.se:d951b6b1-d703-41a3-bb0a-6714d5669408 | |
| 003 | SwePub | |
| 008 | 230217s2023 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/d951b6b1-d703-41a3-bb0a-6714d56694082 URI |
| 024 | 7 | a https://doi.org/10.1007/s10709-023-00182-02 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Najjari, Afefu Tunis El Manar University4 aut |
| 245 | 1 0 | a Physiological and genomic insights into abiotic stress of halophilic archaeon Natrinema altunense 4.1R isolated from a saline ecosystem of Tunisian desert |
| 264 | c 2023-02-16 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2023 |
| 300 | a 20 s. | |
| 520 | a Halophilic archaea are polyextremophiles with the ability to withstand fluctuations in salinity, high levels of ultraviolet radiation, and oxidative stress, allowing them to survive in a wide range of environments and making them an excellent model for astrobiological research. Natrinema altunense 4.1R is a halophilic archaeon isolated from the endorheic saline lake systems, Sebkhas, located in arid and semi-arid regions of Tunisia. It is an ecosystem characterized by periodic flooding from subsurface groundwater and fluctuating salinities. Here, we assess the physiological responses and genomic characterization of N. altunense 4.1R to UV-C radiation, as well as osmotic and oxidative stresses. Results showed that the 4.1R strain is able to survive up to 36% of salinity, up to 180 J/m2 to UV-C radiation, and at 50 mM of H2O2, a resistance profile similar to Halobacterium salinarum, a strain often used as UV-C resistant model. In order to understand the genetic determinants of N. altunense 4.1R survival strategy, we sequenced and analyzed its genome. Results showed multiple gene copies of osmotic stress, oxidative stress, and DNA repair response mechanisms supporting its survivability at extreme salinities and radiations. Indeed, the 3D molecular structures of seven proteins related to responses to UV-C radiation (excinucleases UvrA, UvrB, and UvrC, and photolyase), saline stress (trehalose-6-phosphate synthase OtsA and trehalose-phosphatase OtsB), and oxidative stress (superoxide dismutase SOD) were constructed by homology modeling. This study extends the abiotic stress range for the species N. altunense and adds to the repertoire of UV and oxidative stress resistance genes generally known from haloarchaeon. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
| 650 | 7 | a NATURVETENSKAPx Biologix Mikrobiologi0 (SwePub)106062 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Microbiology0 (SwePub)106062 hsv//eng |
| 653 | a Haloarchaea | |
| 653 | a Natrinema altunense | |
| 653 | a UV-C radiation | |
| 653 | a Oxidative stress | |
| 653 | a Osmotic stress | |
| 653 | a Genomic analysis | |
| 653 | a Molecular modeling | |
| 700 | 1 | a Boussetta, Ayoubu Tunis El Manar University4 aut |
| 700 | 1 | a Youssef, Nohau Oklahoma State University, Stillwater4 aut |
| 700 | 1 | a Linares-Pastén, Javier A.u Lund University,Lunds universitet,Bioteknik,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biotechnology,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)biot-jlp |
| 700 | 1 | a Mahjoubi, Mounau University of Manouba4 aut |
| 700 | 1 | a Belloum, Rahmau Tunis El Manar University4 aut |
| 700 | 1 | a Sghaier, Haithamu National Center for Nuclear Sciences and Technology, Tunisia4 aut |
| 700 | 1 | a Cherif, Ameuru University of Manouba4 aut |
| 700 | 1 | a Ouzari, Hadda Imeneu Tunis El Manar University4 aut |
| 710 | 2 | a Tunis El Manar Universityb Oklahoma State University, Stillwater4 org |
| 773 | 0 | t Geneticad : Springer Science and Business Media LLCg 151:2, s. 133-152q 151:2<133-152x 1573-6857x 0016-6707 |
| 856 | 4 | u http://dx.doi.org/10.1007/s10709-023-00182-0x freey FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/d951b6b1-d703-41a3-bb0a-6714d5669408 |
| 856 | 4 8 | u https://doi.org/10.1007/s10709-023-00182-0 |
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