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Sökning: onr:"swepub:oai:lup.lub.lu.se:e17c4fa6-4098-4455-818e-3ad056a46f95" > Galectin-3 Decrease...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004301naa a2200505 4500
001oai:lup.lub.lu.se:e17c4fa6-4098-4455-818e-3ad056a46f95
003SwePub
008221006s2022 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/e17c4fa6-4098-4455-818e-3ad056a46f952 URI
0247 a https://doi.org/10.3389/fimmu.2022.9158902 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Nielsen, Morten Aagaardu Aarhus University Hospital,Aarhus University4 aut
2451 0a Galectin-3 Decreases 4-1BBL Bioactivity by Crosslinking Soluble and Membrane Expressed 4-1BB
264 c 2022-06-24
264 1b Frontiers Media SA,c 2022
520 a 4-1BB is a T cell costimulatory receptor and a member of the tumor necrosis factor receptor superfamily. Here, we show that Galectin-3 (Gal-3) decreases the cellular response to its ligand (4-1BBL). Gal-3 binds to both soluble 4-1BB (s4-1BB) and membrane-bound 4-1BB (mem4-1BB), without blocking co-binding of 4-1BBL. In plasma, we detected complexes composed of 4-1BB and Gal-3 larger than 100 nm in size; these complexes were reduced in synovial fluid from rheumatoid arthritis. Both activated 4-1BB+ T cells and 4-1BB-transfected HEK293 cells depleted these complexes from plasma, followed by increased expression of 4-1BB and Gal-3 on the cell surface. The increase was accompanied by a 4-fold decrease in TNFα production by the 4-1BBhighGal-3+ T cells, after exposure to 4-1BB/Gal-3 complexes. In RA patients, complexes containing 4-1BB/Gal-3 were dramatically reduced in both plasma and SF compared with healthy plasma. These results support that Gal-3 binds to 4-1BB without blocking the co-binding of 4-1BBL. Instead, Gal-3 leads to formation of large soluble 4-1BB/Gal-3 complexes that attach to mem4-1BB on the cell surfaces, resulting in suppression of 4-1BBL’s bioactivity.
650 7a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
653 a 4-1BB
653 a checkpoint receptor
653 a Galectin-3
653 a inflammation
653 a rheumatoid arthritis
7001 a Juul-Madsen, Kristianu Aarhus University4 aut
7001 a Stegmayr, Johnu Lund University,Lunds universitet,Lungbioengineering och regeneration,Forskargrupper vid Lunds universitet,LTH profilområde: Nanovetenskap och halvledarteknologi,LTH profilområden,Lunds Tekniska Högskola,Lung Bioengineering and Regeneration,Lund University Research Groups,LTH Profile Area: Nanoscience and Semiconductor Technology,LTH Profile areas,Faculty of Engineering, LTH4 aut0 (Swepub:lu)cob-jns
7001 a Gao, Chaou Harvard Medical School4 aut
7001 a Mehta, Akul Y.u Harvard Medical School4 aut
7001 a Greisen, Stinne Ravnu Aarhus University,Aarhus University Hospital4 aut
7001 a Kragstrup, Tue Wenzelu Aarhus University,Aarhus University Hospital4 aut
7001 a Hvid, Maleneu Aarhus University4 aut
7001 a Vorup-Jensen, Thomasu Aarhus University4 aut
7001 a Cummings, Richard D.u Harvard Medical School4 aut
7001 a Leffler, Hakonu Lund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)mmb-hle
7001 a Deleuran, Bent Windingu Aarhus University Hospital,Aarhus University4 aut
7102 a Aarhus University Hospitalb Aarhus University4 org
7730 t Frontiers in Immunologyd : Frontiers Media SAg 13q 13x 1664-3224
8564 u http://dx.doi.org/10.3389/fimmu.2022.915890x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/e17c4fa6-4098-4455-818e-3ad056a46f95
8564 8u https://doi.org/10.3389/fimmu.2022.915890

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