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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004135naa a2200433 4500
001oai:lup.lub.lu.se:e8d7ef7a-50b4-48da-b45c-c6cd5783e71f
003SwePub
008220412s2021 | |||||||||||000 ||eng|
024a https://lup.lub.lu.se/record/e8d7ef7a-50b4-48da-b45c-c6cd5783e71f2 URI
024a https://doi.org/10.1111/joim.133002 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
100a Romanova, E. S.u North-Western State Medical University named after I.I. Mechnikov4 aut
2451 0a Cause of death based on systematic post-mortem studies in patients with positive SARS-CoV-2 tissue PCR during the COVID-19 pandemic
264 c 2021-05-20
264 1b Wiley,c 2021
300 a 11 s.
520 a Importance: Assessment of the causative association between the COVID-19 and cause of death has been hampered by limited availability of systematically performed autopsies. We aimed to present autopsy-confirmed causes of death in patients who died with COVID-19 and to assess the association between thrombosis and diffuse alveolar damage consistent with COVID-19 (DAD). Methods: Consecutive forensic (n = 60) and clinical (n = 42) autopsies with positive post-mortem SARS-CoV-2 PCR in lungs (age 73 ± 14 years, 50% men) were included. The cause of death analysis was based on a review of medical records and histological reports. Thrombotic phenomena in lungs were defined as pulmonary thromboembolism (PE), thrombosis in pulmonary artery branches or microangiopathy in capillary vessels. Results: COVID-19 caused or contributed to death in 71% of clinical and 83% of forensic autopsies, in whom significant DAD was observed. Of the patients with COVID-19 as the primary cause of death, only 19% had no thrombotic phenomena in the lungs, as opposed to 38% amongst those with COVID-19 as a contributing cause of death and 54% amongst patients whose death was not related to COVID-19 (p = 0.002). PE was observed in 5 patients. Two patients fulfilled the criteria for lymphocyte myocarditis. Conclusions: Vast majority of all PCR-positive fatalities, including out-of-hospital deaths, during the SARS-CoV-2 pandemic were related to DAD caused by COVID-19. Pulmonary artery thrombosis and microangiopathy in pulmonary tissue were common and associated with the presence of DAD, whilst venous PE was rarely observed. Histology-confirmed lymphocyte myocarditis was a rare finding.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a COVID-19
653 a forensic autopsy
653 a pathology
700a Vasilyev, V. V.u North-Western State Medical University named after I.I. Mechnikov4 aut
700a Startseva, G.u North-Western State Medical University named after I.I. Mechnikov4 aut
700a Karev, V.u Pediatric Research and Clinical Center for Infectious Diseases, St. Petersburg4 aut
700a Rybakova, M. G.u Pavlov University4 aut
700a Platonov, P. G.u Lund University,Lunds universitet,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Lund University Research Groups4 aut0 (Swepub:lu)kard-ppl
710a North-Western State Medical University named after I.I. Mechnikovb Pediatric Research and Clinical Center for Infectious Diseases, St. Petersburg4 org
773t Journal of Internal Medicined : Wileyg 290:3, s. 655-665q 290:3<655-665x 0954-6820x 1365-2796
856u http://dx.doi.org/10.1111/joim.13300x freey FULLTEXT
856u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250818
8564 8u https://lup.lub.lu.se/record/e8d7ef7a-50b4-48da-b45c-c6cd5783e71f
8564 8u https://doi.org/10.1111/joim.13300

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Romanova, E. S.
Vasilyev, V. V.
Startseva, G.
Karev, V.
Rybakova, M. G.
Platonov, P. G.
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