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Surgical Complicati...
Surgical Complications in Postchemotherapy Retroperitoneal Lymph Node Dissection for Nonseminoma Germ Cell Tumour : A Population-based Study from the Swedish Norwegian Testicular Cancer Group
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- Gerdtsson, Axel (författare)
- Karolinska Institutet,Karolinska Institute,Department of Clinical Science, Intervention and Technology, Division of Urology, Karolinska Institutet, Stockholm, Sweden; Department of Urology, Skåne University Hospital, Malmö, Sweden
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- Håkansson, Ulf (författare)
- GHP Gastro Center Skåne,Gastrocenter, Lund, Sweden
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- Törnblom, Magnus (författare)
- Karolinska Institute,Department of Clinical Science and Education, Section of Urology, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden; Department of Surgery, Visby County Hospital, Visby, Sweden
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- Jancke, George (författare)
- Linköping University Hospital,Region Östergötland, Urologiska kliniken i Östergötland
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- Negaard, Helene F.S. (författare)
- Department of Oncology, Oslo University Hospital, Oslo, Norway
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- Glimelius, Ingrid, 1975- (författare)
- Karolinska Institutet,Uppsala universitet,Uppsala University,Experimentell och klinisk onkologi,Department of Immunology, Genetics and Pathology, Unit of Clinical and Experimental Oncology, Uppsala University, Sweden
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- Halvorsen, Dag (författare)
- Department of Urology, St. Olavs University Hospital, Trondheim, Norway
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- Karlsdóttir, Ása (författare)
- Department of Oncology, Haukeland University Hospital, Bergen, Norway
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- Haugnes, Hege Sagstuen (författare)
- Department of Oncology, University Hospital of North Norway, Tromsø, Norway; Department of Clinical Medicine, UIT-The Arctic University of Norway, Tromsø, Norway
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- Andreassen, Kristine Engen (författare)
- Department of Oncology, Oslo University Hospital, Oslo, Norway
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- Larsen, Signe Melsen (författare)
- Department of Urology, Oslo University Hospital, Oslo, Norway
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- Holmberg, Göran (författare)
- Department of Urology, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Wahlqvist, Rolf (författare)
- Department of Urology, Oslo University Hospital, Oslo, Norway
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- Tandstad, Torgrim (författare)
- St. Olav’s University Hospital,The Cancer Clinic, St; Department of Clinical and Molecular Medicine, The Norwegian University of Science and Technology, Trondheim, Norway
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- Cohn-Cedermark, Gabriella (författare)
- Karolinska Institutet,Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden; PO Bäckencancer, Karolinska University Hospital, Stockholm, Sweden
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- Ståhl, Olof (författare)
- Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Oncology, Skåne University Hospital, Lund, Sweden; Department of Clinical Sciences, Lund University, Lund, Sweden
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- Kjellman, Anders (författare)
- Karolinska Institutet,Department of Clinical Science, Intervention and Technology, Division of Urology, Karolinska Institutet, Stockholm, Sweden; Department of Urology, Pelvic Cancer, Karolinska University Hospital, Stockholm, Sweden
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- Engelska 8 s.
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Ingår i: European Urology Oncology. - : Elsevier BV. - 2588-9311. ; 3:3, s. 382-389
- Relaterad länk:
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http://dx.doi.org/10...
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https://ntnuopen.ntn...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Reports on perioperative complications after postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) for nonseminoma germ cell tumour (NSGCT) are from experienced single centres, with a lack of population-based studies. OBJECTIVE: To assess the complications of bilateral and unilateral PC-RPLND. DESIGN, SETTING, AND PARTICIPANTS: A prospective, population-based, observational multicentre study included all patients with NSGCT who underwent PC-RPLND in Norway and Sweden during 2007-2014. Of a total of 318 patients, 87 underwent bilateral PC-RPLND and 231 underwent unilateral PC-RPLND. The median follow-up was 6 yr. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Bilateral and unilateral PC-RPLND were compared for the outcomes of intra- and postoperative complications (graded by Clavien-Dindo) and retrograde ejaculation (with or without nerve-sparing surgery). Complications were reported as absolute counts and percentages. The χ2 test was used for comparisons. RESULTS AND LIMITATIONS: The incidence of intraoperative complications was higher for bilateral PC-RPLND than for unilateral PC-RPLND (14% vs 4.3%, p = 0.003), with ureteral injury as the most frequent reported complication (2% of the patients). Postoperative complications were more common after bilateral than after unilateral PC-RPLND (45% vs 25%, p = 0.001) with Clavien ≥3b reported in 8.3% and 2.2%, respectively (p = 0.009). Lymphatic leakage was the most common complication occurring in 11% of the patients. Retrograde ejaculation occurred more frequently after bilateral than after unilateral surgery (59% vs 32%, p < 0.001). Limitations of the study include reporting of retrograde ejaculation, which was based on a chart review. CONCLUSIONS: Intra- and postoperative complications including retrograde ejaculation are more frequent after bilateral PC-RPLND than after unilateral PC-RPLND. PATIENT SUMMARY: Lymph node dissection in patients with testicular cancer puts them at risk of complications. In this study, we present the complications after lymph node dissection.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- LANTBRUKSVETENSKAPER -- Veterinärmedicin -- Patobiologi (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science -- Pathobiology (hsv//eng)
Nyckelord
- Complications
- Nonseminoma
- Postchemotherapy retroperitoneal lymph node dissection
- Retrograde ejaculation
- Testicular cancer
- Complications
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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- Av författaren/redakt...
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Gerdtsson, Axel
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Håkansson, Ulf
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Törnblom, Magnus
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Jancke, George
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Negaard, Helene ...
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Glimelius, Ingri ...
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visa fler...
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Halvorsen, Dag
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Karlsdóttir, Ása
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Haugnes, Hege Sa ...
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Andreassen, Kris ...
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Larsen, Signe Me ...
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Holmberg, Göran
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Wahlqvist, Rolf
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Tandstad, Torgri ...
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Cohn-Cedermark, ...
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Ståhl, Olof
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Kjellman, Anders
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
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- LANTBRUKSVETENSKAPER
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LANTBRUKSVETENSK ...
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och Veterinärmedicin
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och Patobiologi
- Artiklar i publikationen
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European Urology ...
- Av lärosätet
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Lunds universitet
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Uppsala universitet
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Karolinska Institutet
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Linköpings universitet