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Sökning: onr:"swepub:oai:lup.lub.lu.se:eee109e9-90ea-4596-ba79-330d87c2ac1a" > Serious life events...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005062naa a2200505 4500
001oai:lup.lub.lu.se:eee109e9-90ea-4596-ba79-330d87c2ac1a
003SwePub
008170822s2017 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:136412941
009oai:DiVA.org:uu-333745
0247 a https://lup.lub.lu.se/record/eee109e9-90ea-4596-ba79-330d87c2ac1a2 URI
0247 a https://doi.org/10.1111/dme.134102 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1364129412 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3337452 URI
040 a (SwePub)lud (SwePub)kid (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Rasouli, B.u Karolinska Institutet,Karolinska Inst, Inst Environm Med, Stockholm, Sweden.4 aut
2451 0a Serious life events and the risk of latent autoimmune diabetes in adults (LADA) and Type 2 diabetes
264 c 2017-07-12
264 1b Wiley,c 2017
520 a Aim: It has been suggested that experiencing serious life events may promote Type 1 diabetes in children. Studies in adults are lacking, as are studies on the interaction of life events with genetic factors. We aimed to investigate life events and the risk of latent autoimmune diabetes in adults (LADA) and Type 2 diabetes while taking into account HLA genotype. Methods: Analysis was based on 425 incident cases of LADA, 1417 incident cases of Type 2 diabetes and 1702 population-based controls recruited in Sweden between 2010 and 2016. Self-reported information on life events including conflicts, divorce, illness/accidents, death and financial problems experienced during the 5 years preceding diagnosis/index year was used. Odds ratios (ORs) and 95% confidence intervals (95% CI) were calculated by logistic regression and adjusted for age, sex, BMI, family history of diabetes, smoking, physical activity and education. Results: Overall there was no association between experience of any life event and either LADA (OR 0.86, 95% CI 0.68-1.08) or Type 2 diabetes (OR 1.00, 95% CI 0.83-1.21). The results were similar for individual events as well as in separate analysis of men and women. Similar results were seen in more autoimmune LADA (glutamic acid decarboxylase antibodies > median) [OR (any life event) 0.88, 95% CI 0.64-1.21] and in LADA carriers of the high-risk HLADR4-DQ8 genotype (OR 0.89, 95% CI 0.61-1.29). Conclusions: Our findings indicate that experience of a serious life event, including the death of a family member, divorce or financial problems, is not associated with an increased risk of LADA, overall or in genetically susceptible individuals.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a ANDIS
653 a diabetes
653 a diabetics
7001 a Andersson, T.u Karolinska Institutet,Karolinska Inst, Inst Environm Med, Stockholm, Sweden.;Stockholm Cty Council, Ctr Occupat & Environm Med, Stockholm, Sweden.4 aut
7001 a Carlsson, P.-O.u Uppsala University,Uppsala Univ, Dept Med Sci, Uppsala, Sweden.4 aut
7001 a Hjort, R.u Karolinska Institutet,Karolinska Inst, Inst Environm Med, Stockholm, Sweden.4 aut
7001 a Löfvenborg, J Eu Karolinska Institutet,Karolinska Inst, Inst Environm Med, Stockholm, Sweden.4 aut
7001 a Martinell, Mats,d 1971-u Uppsala universitet,Uppsala University,Allmänmedicin och preventivmedicin4 aut0 (Swepub:uu)matma554
7001 a Groop, L.u Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,University of Helsinki,Lund Univ, Dept Clin Sci Malmo, Clin Res Ctr, Malmo, Sweden.;Univ Helsinki, Finnish Inst Mol Med, Helsinki, Finland.4 aut0 (Swepub:lu)endo-lgr
7001 a Tuomi, T.u University of Helsinki,Univ Helsinki, Helsinki Univ Hosp, Abdominal Ctr, Res Program Diabet & Obes,Div Endocrinol, Helsinki, Finland.;Folkhalsan Res Ctr, Helsinki, Finland.4 aut0 (Swepub:lu)ti8736tu
7001 a Carlsson, S.u Karolinska Institutet,Karolinska Inst, Inst Environm Med, Stockholm, Sweden.4 aut
7102 a Karolinska Institutetb Karolinska Inst, Inst Environm Med, Stockholm, Sweden.4 org
7730 t Diabetic Medicined : Wileyg 34:9, s. 1259-1263q 34:9<1259-1263x 0742-3071x 1464-5491
7730 t Diabetic medicine : a journal of the British Diabetic Associationd : Wileyg 34:9, s. 1259-1263q 34:9<1259-1263x 1464-5491
8564 u http://dx.doi.org/10.1111/dme.13410y FULLTEXT
8564 8u https://lup.lub.lu.se/record/eee109e9-90ea-4596-ba79-330d87c2ac1a
8564 8u https://doi.org/10.1111/dme.13410
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:136412941
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-333745

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