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Sökning: onr:"swepub:oai:lup.lub.lu.se:f208bf2b-2108-4200-9cec-b47449aec8ca" > The tale of TILs in...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005026naa a2200901 4500
001oai:lup.lub.lu.se:f208bf2b-2108-4200-9cec-b47449aec8ca
003SwePub
008211201s2021 | |||||||||||000 ||eng|
024a https://lup.lub.lu.se/record/f208bf2b-2108-4200-9cec-b47449aec8ca2 URI
024a https://doi.org/10.1038/s41523-021-00346-12 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a for2 swepub-publicationtype
072 7a ref2 swepub-contenttype
100a El Bairi, Khalidu Mohamed Premier University4 aut
2451 0a The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group
264 c 2021-12-01
264 1b Springer Science and Business Media LLC,c 2021
520 a The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes with expression of programmed death-ligand 1 (PD-L1). These patients may potentially benefit from ICI targeting the programmed death 1 (PD-1)/PD-L1 signaling axis. The use of tumor-infiltrating lymphocytes (TILs) as predictive and prognostic biomarkers has been under intense examination. Emerging data suggest that TILs are associated with response to both cytotoxic treatments and immunotherapy, particularly for patients with triple-negative BC. In this review from The International Immuno-Oncology Biomarker Working Group, we discuss (a) the biological understanding of TILs, (b) their analytical and clinical validity and efforts toward the clinical utility in BC, and (c) the current status of PD-L1 and TIL testing across different continents, including experiences from low-to-middle-income countries, incorporating also the view of a patient advocate. This information will help set the stage for future approaches to optimize the understanding and clinical utilization of TIL analysis in patients with BC.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
700a Haynes, Harry R.4 aut
700a Blackley, Elizabeth4 aut
700a Fineberg, Susan4 aut
700a Shear, Jeffrey4 aut
700a Turner, Sophia4 aut
700a De Freitas, Juliana Ribeiro4 aut
700a Sur, Daniel4 aut
700a Amendola, Luis Claudio4 aut
700a Gharib, Masoumeh4 aut
700a Kallala, Amine4 aut
700a Arun, Indu4 aut
700a Azmoudeh-ardalan, Farid4 aut
700a Fujimoto, Luciana4 aut
700a Sua, Luz F.4 aut
700a Liu, Shi-wei4 aut
700a Lien, Huang-chun4 aut
700a Kirtani, Pawan4 aut
700a Balancin, Marcelo4 aut
700a El Attar, Hicham4 aut
700a Guleria, Prerna4 aut
700a Yang, Wenxian4 aut
700a Shash, Emad4 aut
700a Chen, I-chun4 aut
700a Bautista, Veronica4 aut
700a Do Prado Moura, Jose Fernando4 aut
700a Rapoport, Bernardo L.4 aut
700a Castaneda, Carlos4 aut
700a Spengler, Eunice4 aut
700a Acosta-haab, Gabriela4 aut
700a Frahm, Isabel4 aut
700a Sanchez, Joselyn4 aut
700a Castillo, Miluska4 aut
700a Bouchmaa, Najat4 aut
700a Md Zin, Reena R.4 aut
700a Shui, Ruohong4 aut
700a Onyuma, Timothy4 aut
700a Yang, Wentao4 aut
700a Husain, Zaheed4 aut
700a Willard-gallo, Karen4 aut
700a Coosemans, An4 aut
700a Perez, Edith A.4 aut
700a Provenzano, Elena4 aut
700a Ericsson, Paula Gonzalez4 aut
700a Richardet, Eduardo4 aut
700a Mehrotra, Ravi4 aut
700a Ehinger, Annau Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pat-amm
700a Brown, Mark4 aut
700a Lundin, Johan4 aut
700a Loi, Shereneu University of Melbourne4 aut
710a Mohamed Premier Universityb LUCC: Lunds universitets cancercentrum4 org
710a International Immuno-Oncology Biomarker Working Group
773t npj Breast Cancerd : Springer Science and Business Media LLCg 7:1q 7:1x 2374-4677
856u http://dx.doi.org/10.1038/s41523-021-00346-1x freey FULLTEXT
856u https://www.nature.com/articles/s41523-021-00346-1.pdf
8564 8u https://lup.lub.lu.se/record/f208bf2b-2108-4200-9cec-b47449aec8ca
8564 8u https://doi.org/10.1038/s41523-021-00346-1

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