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Sökning: onr:"swepub:oai:lup.lub.lu.se:fda5b2b5-3bca-4963-be9e-21cf918cb2e5" > Variation of breast...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004268naa a2200481 4500
001oai:lup.lub.lu.se:fda5b2b5-3bca-4963-be9e-21cf918cb2e5
003SwePub
008160404s2008 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/11444662 URI
0247 a https://doi.org/10.1001/jama.2007.55-a2 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Begg, Colin B4 aut
2451 0a Variation of breast cancer risk among BRCA1/2 carriers
264 1b American Medical Association (AMA),c 2008
520 a CONTEXT: The risk of breast cancer in BRCA1 and BRCA2 mutation carriers has been examined in many studies, but relatively little attention has been paid to the degree to which the risk may vary among carriers. OBJECTIVES: To determine the extent to which risks for BRCA1 and BRCA2 carriers vary with respect to observable and unobservable characteristics. DESIGN, SETTING, AND PARTICIPANTS: Probands were identified from a population-based, case-control study (Women's Environmental Cancer and Radiation Epidemiology [WECARE]) of asynchronous contralateral breast cancer conducted during the period of January 2000 to July 2004. Participants previously diagnosed with contralateral breast cancer or unilateral breast cancer were genotyped for mutations in BRCA1 and BRCA2. All participants had their initial breast cancer diagnosed during the period of January 1985 to December 2000, before the age of 55 years. MAIN OUTCOME MEASURE: Incidence of breast cancer in first-degree female relatives of the probands was examined and compared on the basis of proband characteristics and on the basis of variation between families. RESULTS: Among the 1394 participants with unilateral breast cancer, 73 (5.2%) were identified as carriers of deleterious mutations (42 with BRCA1 and 31 with BRCA2). Among the 704 participants with contralateral breast cancer, 108 (15.3%) were identified as carriers of deleterious mutations (67 with BRCA1 and 41 with BRCA2). Among relatives of carriers, risk was significantly associated with younger age at diagnosis in the proband (P = .04), and there was a trend toward higher risk for relatives of contralateral breast cancer vs unilateral breast cancer participants (odds ratio, 1.4 [95% confidence interval, 0.8-2.4]; P = .28). In addition, there were significant differences in risk between carrier families after adjusting for these observed characteristics. CONCLUSION: There exists broad variation in breast cancer risk among carriers of BRCA1 and BRCA2 mutations.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Haile, Robert W4 aut
7001 a Borg, Åkeu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-abo
7001 a Malone, Kathleen E4 aut
7001 a Concannon, Patrick4 aut
7001 a Thomas, Duncan C4 aut
7001 a Langholz, Bryan4 aut
7001 a Bernstein, Leslie4 aut
7001 a Olsen, Jorgen H4 aut
7001 a Lynch, Charles F4 aut
7001 a Anton-Culver, Hoda4 aut
7001 a Capanu, Marinela4 aut
7001 a Liang, Xiaolin4 aut
7001 a Hummer, Amanda J4 aut
7001 a Sima, Cami4 aut
7102 a Bröstcancer-genetikb Sektion I4 org
7730 t JAMA: The Journal of the American Medical Associationd : American Medical Association (AMA)g 299:2, s. 194-201q 299:2<194-201x 1538-3598
7730 t JAMAd : American Medical Association (AMA)g 299:2, s. 194-201q 299:2<194-201x 0098-7484
8564 u http://jama.ama-assn.org/cgi/content/abstract/299/2/194y FULLTEXT
8564 u http://dx.doi.org/10.1001/jama.2007.55-ay FULLTEXT
8564 u https://jamanetwork.com/journals/jama/articlepdf/1149366/joc70145_194_201.pdf
8564 8u https://lup.lub.lu.se/record/1144466
8564 8u https://doi.org/10.1001/jama.2007.55-a

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