A variant in FTO shows association with melanoma risk not due to BMI

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Iles, Mark M. (author)

A variant in FTO shows association with melanoma risk not due to BMI

Article/chapterEnglish2013

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2013-03-03
Springer Science and Business Media LLC,2013

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LIBRIS-ID:oai:lup.lub.lu.se:fe22906b-6821-4428-99a8-851310dde0be
https://lup.lub.lu.se/record/3748993URI
https://doi.org/10.1038/ng.2571DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:126492457URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

Notes

We report the results of an association study of melanoma that is based on the genome-wide imputation of the genotypes of 1,353 cases and 3,566 controls of European origin conducted by the GenoMEL consortium. This revealed an association between several SNPs in intron 8 of the FTO gene, including rs16953002, which replicated using 12,313 cases and 55,667 controls of European ancestry from Europe, the USA and Australia (combined P = 3.6 x 10(-12), per-allele odds ratio for allele A = 1.16). In addition to identifying a new melanomasusceptibility locus, this is to our knowledge the first study to identify and replicate an association with SNPs in FTO not related to body mass index (BMI). These SNPs are not in intron 1 (the BMI-related region) and exhibit no association with BMI. This suggests FTO's function may be broader than the existing paradigm that FTO variants influence multiple traits only through their associations with BMI and obesity.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng

Added entries (persons, corporate bodies, meetings, titles ...)

Law, Matthew H. (author)
Stacey, Simon N. (author)
Han, Jiali (author)
Fang, Shenying (author)
Pfeiffer, Ruth (author)
Harland, Mark (author)
MacGregor, Stuart (author)
Taylor, John C. (author)
Aben, Katja K. (author)
Akslen, Lars A. (author)
Avril, Marie-Francoise (author)
Azizi, Esther (author)
Bakker, Bert (author)
Benediktsdottir, Kristrun R. (author)
Bergman, Wilma (author)
Scarra, Giovanna Bianchi (author)
Brown, Kevin M. (author)
Calista, Donato (author)
Chaudru, Valerie (author)
Fargnoli, Maria Concetta (author)
Cust, Anne E. (author)
Demenais, Florence (author)
Waal, Anne C. de (author)
Debniak, Tadeusz (author)
Elder, David E. (author)
Friedman, Eitan (author)
Galan, Pilar (author)
Ghiorzo, Paola (author)
Gillanders, Elizabeth M. (author)
Goldstein, Alisa M. (author)
Gruis, Nelleke A. (author)
Hansson, JohanKarolinska Institutet (author)
Helsing, Per (author)
Hocevar, Marko (author)
Hoiom, VeronicaKarolinska Institutet (author)
Hopper, John L. (author)
Ingvar, ChristianLund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)kir-cin (author)
Janssen, Marjolein (author)
Jenkins, Mark A. (author)
Kanetsky, Peter A. (author)
Kiemeney, Lambertus A. (author)
Lang, Julie (author)
Lathrop, G. Mark (author)
Leachman, Sancy (author)
Lee, Jeffrey E. (author)
Lubinski, Jan (author)
Mackie, Rona M. (author)
Mann, Graham J. (author)
Martin, Nicholas G. (author)
Mayordomo, Jose I. (author)
Molven, Anders (author)
Mulder, Suzanne (author)
Nagore, Eduardo (author)
Novakovic, Srdjan (author)
Okamoto, Ichiro (author)
Olafsson, Jon H. (author)
Olsson, HåkanLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-hol (author)
Pehamberger, Hubert (author)
Peris, Ketty (author)
Grasa, Maria Pilar (author)
Planelles, Dolores (author)
Puig, Susana (author)
Puig-Butille, Joan Anton (author)
Randerson-Moor, Juliette (author)
Requena, Celia (author)
Rivoltini, Licia (author)
Rodolfo, Monica (author)
Santinami, Mario (author)
Sigurgeirsson, Bardur (author)
Snowden, Helen (author)
Song, Fengju (author)
Sulem, Patrick (author)
Thorisdottir, Kristin (author)
Tuominen, RainerKarolinska Institutet (author)
Van Belle, Patricia (author)
van der Stoep, Nienke (author)
van Rossum, Michelle M. (author)
Wei, Qingyi (author)
Wendt, Judith (author)
Zelenika, Diana (author)
Zhang, Mingfeng (author)
Landi, Maria Teresa (author)
Thorleifsson, Gudrnar (author)
Bishop, D. Timothy (author)
Amos, Christopher I. (author)
Hayward, Nicholas K. (author)
Stefansson, Kari (author)
Bishop, Julia A. Newton (author)
Barrett, Jennifer H. (author)
Karolinska InstitutetKirurgi, Lund (creator_code:org_t)

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In:Nature Genetics: Springer Science and Business Media LLC45:4, s. 428-4321546-17181061-4036

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By the author/editor: Iles, Mark M.; Law, Matthew H.; Stacey, Simon N.; Han, Jiali; Fang, Shenying; Pfeiffer, Ruth; show more...; Harland, Mark; MacGregor, Stuar ...; Taylor, John C.; Aben, Katja K.; Akslen, Lars A.; Avril, Marie-Fra ...; Azizi, Esther; Bakker, Bert; Benediktsdottir, ...; Bergman, Wilma; Scarra, Giovanna ...; Brown, Kevin M.; Calista, Donato; Chaudru, Valerie; Fargnoli, Maria ...; Cust, Anne E.; Demenais, Floren ...; Waal, Anne C. de; Debniak, Tadeusz; Elder, David E.; Friedman, Eitan; Galan, Pilar; Ghiorzo, Paola; Gillanders, Eliz ...; Goldstein, Alisa ...; Gruis, Nelleke A ...; Hansson, Johan; Helsing, Per; Hocevar, Marko; Hoiom, Veronica; Hopper, John L.; Ingvar, Christia ...; Janssen, Marjole ...; Jenkins, Mark A.; Kanetsky, Peter ...; Kiemeney, Lamber ...; Lang, Julie; Lathrop, G. Mark; Leachman, Sancy; Lee, Jeffrey E.; Lubinski, Jan; Mackie, Rona M.; Mann, Graham J.; Martin, Nicholas ...; Mayordomo, Jose ...; Molven, Anders; Mulder, Suzanne; Nagore, Eduardo; Novakovic, Srdja ...; Okamoto, Ichiro; Olafsson, Jon H.; Olsson, Håkan; Pehamberger, Hub ...; Peris, Ketty; Grasa, Maria Pil ...; Planelles, Dolor ...; Puig, Susana; Puig-Butille, Jo ...; Randerson-Moor, ...; Requena, Celia; Rivoltini, Licia; Rodolfo, Monica; Santinami, Mario; Sigurgeirsson, B ...; Snowden, Helen; Song, Fengju; Sulem, Patrick; Thorisdottir, Kr ...; Tuominen, Rainer; Van Belle, Patri ...; van der Stoep, N ...; van Rossum, Mich ...; Wei, Qingyi; Wendt, Judith; Zelenika, Diana; Zhang, Mingfeng; Landi, Maria Ter ...; Thorleifsson, Gu ...; Bishop, D. Timot ...; Amos, Christophe ...; Hayward, Nichola ...; Stefansson, Kari; Bishop, Julia A. ...; Barrett, Jennife ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Surgery

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

Articles in the publication: Nature Genetics

By the university: Lund University; Karolinska Institutet

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