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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04906naa a2200973 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:132502923 | |
| 003 | SwePub | |
| 008 | 240811s2015 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:umu-113741 | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1325029232 URI |
| 024 | 7 | a https://doi.org/10.1183/13993003.00779-20152 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1137412 URI |
| 040 | a (SwePub)kid (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Shaw, DEu Karolinska Institutet4 aut |
| 245 | 1 0 | a Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort |
| 264 | c 2015-09-10 | |
| 264 | 1 | b European Respiratory Society (ERS),c 2015 |
| 520 | a U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical companies and six patient organisations with the objective of improving the understanding of asthma disease mechanisms using a systems biology approach.This cross-sectional assessment of adults with severe asthma, mild/moderate asthma and healthy controls from 11 European countries consisted of analyses of patient-reported outcomes, lung function, blood and airway inflammatory measurements.Patients with severe asthma (nonsmokers, n=311; smokers/ex-smokers, n=110) had more symptoms and exacerbations compared to patients with mild/moderate disease (n=88) (2.5 exacerbations versus 0.4 in the preceding 12 months; p<0.001), with worse quality of life, and higher levels of anxiety and depression. They also had a higher incidence of nasal polyps and gastro-oesophageal reflux with lower lung function. Sputum eosinophil count was higher in severe asthma compared to mild/moderate asthma (median count 2.99% versus 1.05%; p=0.004) despite treatment with higher doses of inhaled and/or oral corticosteroids.Consistent with other severe asthma cohorts, U-BIOPRED is characterised by poor symptom control, increased comorbidity and airway inflammation, despite high levels of treatment. It is well suited to identify asthma phenotypes using the array of “omic” datasets that are at the core of this systems medicine approach. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng |
| 700 | 1 | a Sousa, AR4 aut |
| 700 | 1 | a Fowler, SJ4 aut |
| 700 | 1 | a Fleming, LJ4 aut |
| 700 | 1 | a Roberts, G4 aut |
| 700 | 1 | a Corfield, J4 aut |
| 700 | 1 | a Pandis, I4 aut |
| 700 | 1 | a Bansal, AT4 aut |
| 700 | 1 | a Bel, EH4 aut |
| 700 | 1 | a Auffray, C4 aut |
| 700 | 1 | a Compton, CH4 aut |
| 700 | 1 | a Bisgaard, H4 aut |
| 700 | 1 | a Bucchioni, E4 aut |
| 700 | 1 | a Caruso, M4 aut |
| 700 | 1 | a Chanez, P4 aut |
| 700 | 1 | a Dahlen, Bu Karolinska Institutet4 aut |
| 700 | 1 | a Dahlen, SEu Karolinska Institutet4 aut |
| 700 | 1 | a Dyson, K4 aut |
| 700 | 1 | a Frey, U4 aut |
| 700 | 1 | a Geiser, T4 aut |
| 700 | 1 | a de Verdier, MG4 aut |
| 700 | 1 | a Gibeon, D4 aut |
| 700 | 1 | a Guo, YK4 aut |
| 700 | 1 | a Hashimoto, S4 aut |
| 700 | 1 | a Hedlin, Gu Karolinska Institutet4 aut |
| 700 | 1 | a Jeyasingham, E4 aut |
| 700 | 1 | a Hekking, PPW4 aut |
| 700 | 1 | a Higenbottam, T4 aut |
| 700 | 1 | a Horvath, I4 aut |
| 700 | 1 | a Knox, AJ4 aut |
| 700 | 1 | a Krug, N4 aut |
| 700 | 1 | a Erpenbeck, VJ4 aut |
| 700 | 1 | a Larsson, LX4 aut |
| 700 | 1 | a Lazarinis, Nu Karolinska Institutet4 aut |
| 700 | 1 | a Matthews, JG4 aut |
| 700 | 1 | a Middelveld, Ru Karolinska Institutet4 aut |
| 700 | 1 | a Montuschi, P4 aut |
| 700 | 1 | a Musial, J4 aut |
| 700 | 1 | a Myles, D4 aut |
| 700 | 1 | a Pahus, L4 aut |
| 700 | 1 | a Sandström, Thomasu Umeå universitet,Lungmedicin4 aut0 (Swepub:umu)thsa0001 |
| 700 | 1 | a Seibold, W4 aut |
| 700 | 1 | a Singer, F4 aut |
| 700 | 1 | a Strandberg, K4 aut |
| 700 | 1 | a Vestbo, J4 aut |
| 700 | 1 | a Vissing, N4 aut |
| 700 | 1 | a von Garnier, C4 aut |
| 700 | 1 | a Adcock, IM4 aut |
| 700 | 1 | a Wagers, S4 aut |
| 700 | 1 | a Rowe, A4 aut |
| 700 | 1 | a Howarth, P4 aut |
| 700 | 1 | a Wagener, AH4 aut |
| 700 | 1 | a Djukanovic, R4 aut |
| 700 | 1 | a Sterk, PJ4 aut |
| 700 | 1 | a Chung, KF4 aut |
| 710 | 2 | a Karolinska Institutetb Lungmedicin4 org |
| 773 | 0 | t The European respiratory journald : European Respiratory Society (ERS)g 46:5, s. 1308-1321q 46:5<1308-1321x 1399-3003x 0903-1936 |
| 856 | 4 | u https://erj.ersjournals.com/content/erj/46/5/1308.full.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:132502923 |
| 856 | 4 8 | u https://doi.org/10.1183/13993003.00779-2015 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-113741 |
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