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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02409naa a2200361 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:132566807 | |
| 003 | SwePub | |
| 008 | 240811s2015 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1325668072 URI |
| 024 | 7 | a https://doi.org/10.1038/ncomms100752 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Tollenaere, MAX4 aut |
| 245 | 1 0 | a p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1 |
| 264 | c 2015-11-30 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2015 |
| 520 | a Centriolar satellites (CS) are small granular structures that cluster in the vicinity of centrosomes. CS are highly susceptible to stress stimuli, triggering abrupt displacement of key CS factors. Here we discover a linear p38-MK2-14-3-3 signalling pathway that specifically targets CEP131 to trigger CS remodelling after cell stress. We identify CEP131 as a substrate of the p38 effector kinase MK2 and pinpoint S47 and S78 as critical MK2 phosphorylation sites in CEP131. Ultraviolet-induced phosphorylation of these residues generates direct binding sites for 14-3-3 proteins, which sequester CEP131 in the cytoplasm to block formation of new CS, thereby leading to rapid depletion of these structures. Mutating S47 and S78 in CEP131 is sufficient to abolish stress-induced CS reorganization, demonstrating that CEP131 is the key regulatory target of MK2 and 14-3-3 in these structures. Our findings reveal the molecular mechanism underlying dynamic CS remodelling to modulate centrosome functions on cell stress. | |
| 700 | 1 | a Villumsen, BH4 aut |
| 700 | 1 | a Blasius, M4 aut |
| 700 | 1 | a Nielsen, JC4 aut |
| 700 | 1 | a Wagner, SA4 aut |
| 700 | 1 | a Bartek, Ju Karolinska Institutet4 aut |
| 700 | 1 | a Beli, P4 aut |
| 700 | 1 | a Mailand, N4 aut |
| 700 | 1 | a Bekker-Jensen, S4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 6, s. 10075-q 6<10075-x 2041-1723 |
| 856 | 4 | u https://www.nature.com/articles/ncomms10075.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:132566807 |
| 856 | 4 8 | u https://doi.org/10.1038/ncomms10075 |
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