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Oncological outcome...
Oncological outcomes, quality of life outcomes and complications of partial cystectomy for selected cases of muscle-invasive bladder cancer
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Ebbing, J (author)
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Heckmann, RC (author)
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Collins, JW (author)
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Miller, K (author)
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Erber, B (author)
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Friedersdorff, F (author)
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Fuller, TF (author)
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Busch, J (author)
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Seifert, HH (author)
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Ardelt, P (author)
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Wetterauer, C (author)
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Hosseini, A (author)
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Jentzmik, F (author)
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Kempkensteffen, C (author)
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- 2018-05-30
- 2018
- English.
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In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 8:1, s. 8360-
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https://www.nature.c...
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https://doi.org/10.1...
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Abstract
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- To evaluate the oncological results, associated complications, and postoperative health-related quality of life (HR-QoL) in patients treated with partial cystectomy (PC) for muscle-invasive bladder cancer (MIBC). 27 patients who underwent open PC for cT2 MIBC were included. A simple Cox’s proportional hazards regression model was used to assess the association of several potential prognostic factors with survival. Postoperative HR-QoL was assessed with the EORTC (European Organisation for the Research and Treatment of Cancer) QLQ-C30 questionnaire version 3.0. Final pathological tumour stages in PC specimen were: pT0: 18.5%, non-MIBC: 3.7%, MIBC: 74.1%, pCIS: 14.8%. Estimated 5-year overall- and progression-free survival rates were 53.7% and 62.1%. Five (18.5%) patients experienced local recurrence with MIBC. Overall, the salvage cystectomy rate was 18.5%. The 90-day mortality rate was 0%. Significant risk factors for progression-free survival were vascular invasion (HR 5.33) and tumour multilocularity (HR 4.5) in the PC specimen, and a ureteric reimplantation during PC (HR 4.53). The rates of intraoperative complications, 30- and 90-day major complications were 7.4%, respectively and 14.8% for overall long-term complications. Postoperatively, median (IQR) global health status and QoL in our PC cohort was 79.2 (52.1–97.9). Open PC can provide adequate cancer control of MIBC with good HR-QoL in highly selected cases. Open PC can lead to long-term bladder preservation and shows an acceptable rate of severe perioperative complications, even in highly comorbid patients.
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- By the author/editor
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Ebbing, J
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Heckmann, RC
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Collins, JW
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Miller, K
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Erber, B
-
Friedersdorff, F
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show more...
-
Fuller, TF
-
Busch, J
-
Seifert, HH
-
Ardelt, P
-
Wetterauer, C
-
Hosseini, A
-
Jentzmik, F
-
Kempkensteffen, ...
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show less...
- Articles in the publication
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Scientific repor ...
- By the university
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Karolinska Institutet