onr:"swepub:oai:prod.swepub.kib.ki.se:140606380"
Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:140606380" > The temporal dynami...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03526naa a2200733 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:140606380 | |
| 003 | SwePub | |
| 008 | 240920s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1406063802 URI |
| 024 | 7 | a https://doi.org/10.1038/s41467-019-09441-12 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Slater, HC4 aut |
| 245 | 1 0 | a The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density |
| 264 | c 2019-03-29 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2019 |
| 520 | a Malaria infections occurring below the limit of detection of standard diagnostics are common in all endemic settings. However, key questions remain surrounding their contribution to sustaining transmission and whether they need to be detected and targeted to achieve malaria elimination. In this study we analyse a range of malaria datasets to quantify the density, detectability, course of infection and infectiousness of subpatent infections. Asymptomatically infected individuals have lower parasite densities on average in low transmission settings compared to individuals in higher transmission settings. In cohort studies, subpatent infections are found to be predictive of future periods of patent infection and in membrane feeding studies, individuals infected with subpatent asexual parasite densities are found to be approximately a third as infectious to mosquitoes as individuals with patent (asexual parasite) infection. These results indicate that subpatent infections contribute to the infectious reservoir, may be long lasting, and require more sensitive diagnostics to detect them in lower transmission settings. | |
| 700 | 1 | a Ross, A4 aut |
| 700 | 1 | a Felger, I4 aut |
| 700 | 1 | a Hofmann, NE4 aut |
| 700 | 1 | a Robinson, L4 aut |
| 700 | 1 | a Cook, J4 aut |
| 700 | 1 | a Goncalves, BP4 aut |
| 700 | 1 | a Bjorkman, Au Karolinska Institutet4 aut |
| 700 | 1 | a Ouedraogo, AL4 aut |
| 700 | 1 | a Morris, Uu Karolinska Institutet4 aut |
| 700 | 1 | a Msellem, M4 aut |
| 700 | 1 | a Koepfli, C4 aut |
| 700 | 1 | a Mueller, I4 aut |
| 700 | 1 | a Tadesse, F4 aut |
| 700 | 1 | a Gadisa, E4 aut |
| 700 | 1 | a Das, S4 aut |
| 700 | 1 | a Domingo, G4 aut |
| 700 | 1 | a Kapulu, M4 aut |
| 700 | 1 | a Midega, J4 aut |
| 700 | 1 | a Owusu-Agyei, S4 aut |
| 700 | 1 | a Nabet, C4 aut |
| 700 | 1 | a Piarroux, R4 aut |
| 700 | 1 | a Doumbo, O4 aut |
| 700 | 1 | a Doumbo, SN4 aut |
| 700 | 1 | a Koram, K4 aut |
| 700 | 1 | a Lucchi, N4 aut |
| 700 | 1 | a Udhayakumar, V4 aut |
| 700 | 1 | a Mosha, J4 aut |
| 700 | 1 | a Tiono, A4 aut |
| 700 | 1 | a Chandramohan, D4 aut |
| 700 | 1 | a Gosling, R4 aut |
| 700 | 1 | a Mwingira, F4 aut |
| 700 | 1 | a Sauerwein, R4 aut |
| 700 | 1 | a Riley, EM4 aut |
| 700 | 1 | a White, NJ4 aut |
| 700 | 1 | a Nosten, F4 aut |
| 700 | 1 | a Imwong, M4 aut |
| 700 | 1 | a Bousema, T4 aut |
| 700 | 1 | a Drakeley, C4 aut |
| 700 | 1 | a Okell, LC4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 10:1, s. 1433-q 10:1<1433-x 2041-1723 |
| 856 | 4 | u https://www.nature.com/articles/s41467-019-09441-1.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:140606380 |
| 856 | 4 8 | u https://doi.org/10.1038/s41467-019-09441-1 |
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- Slater, HC
- Ross, A
- Felger, I
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- Goncalves, BP
- Bjorkman, A
- Ouedraogo, AL
- Morris, U
- Msellem, M
- Koepfli, C
- Mueller, I
- Tadesse, F
- Gadisa, E
- Das, S
- Domingo, G
- Kapulu, M
- Midega, J
- Owusu-Agyei, S
- Nabet, C
- Piarroux, R
- Doumbo, O
- Doumbo, SN
- Koram, K
- Lucchi, N
- Udhayakumar, V
- Mosha, J
- Tiono, A
- Chandramohan, D
- Gosling, R
- Mwingira, F
- Sauerwein, R
- Riley, EM
- White, NJ
- Nosten, F
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- Bousema, T
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